Nucleic Acid-Based Therapy Approaches for Huntington's Disease

Huntington's disease (HD) is caused by a dominant mutation that results in an unstable expansion of a CAG repeat in the huntingtin gene leading to a toxic gain of function in huntingtin protein which causes massive neurodegeneration mainly in the striatum and clinical symptoms associated with t...

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Detalles Bibliográficos
Autores principales: Vagner, Tatyana, Young, Deborah, Mouravlev, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263636/
https://www.ncbi.nlm.nih.gov/pubmed/22288011
http://dx.doi.org/10.1155/2012/358370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263636/
https://www.ncbi.nlm.nih.gov/pubmed/22288011
http://dx.doi.org/10.1155/2012/358370

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