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Pharmacokinetic Study of Perioperative Intravenous Ifosfamide

The use of cancer chemotherapy and hyperthermia as part of a surgical procedure in the management of patients with peritoneal carcinomatosis has gained prominence in recent years with selected patients showing benefit. Patients with peritoneal surface malignancy following cancer resection were treat...

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Detalles Bibliográficos
Autores principales: Van der Speeten, Kurt, Stuart, O. Anthony, Mahteme, Haile, Sugarbaker, Paul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263669/
https://www.ncbi.nlm.nih.gov/pubmed/22312496
http://dx.doi.org/10.1155/2011/185092
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author Van der Speeten, Kurt
Stuart, O. Anthony
Mahteme, Haile
Sugarbaker, Paul H.
author_facet Van der Speeten, Kurt
Stuart, O. Anthony
Mahteme, Haile
Sugarbaker, Paul H.
author_sort Van der Speeten, Kurt
collection PubMed
description The use of cancer chemotherapy and hyperthermia as part of a surgical procedure in the management of patients with peritoneal carcinomatosis has gained prominence in recent years with selected patients showing benefit. Patients with peritoneal surface malignancy following cancer resection were treated with intraperitoneal hyperthermic (41.5–42.5°C) cisplatin and doxorubicin combined with the infusion of systemic ifosfamide chemotherapy. The concentrations of ifosfamide and 4-hydroxyifosfamide were determined in plasma, peritoneal fluid, urine, and when possible, within small tumor nodules less than 1 cm. Plasma concentrations of ifosfamide exceeded peritoneal fluid levels of ifosfamide during the 90 minutes of chemotherapy infusion. Both ifosfamide and 4-hydroxyifosfamide could be recovered from peritoneal tumor nodules throughout the 90 minutes of ifosfamide continuous infusion and exceeded plasma concentrations. 4-Hydroxyifosfamide within peritoneal surface cancer nodules suggested a favorable pharmacologic endpoint in the study of ifosfamide administered in the operating room.
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spelling pubmed-32636692012-02-06 Pharmacokinetic Study of Perioperative Intravenous Ifosfamide Van der Speeten, Kurt Stuart, O. Anthony Mahteme, Haile Sugarbaker, Paul H. Int J Surg Oncol Research Article The use of cancer chemotherapy and hyperthermia as part of a surgical procedure in the management of patients with peritoneal carcinomatosis has gained prominence in recent years with selected patients showing benefit. Patients with peritoneal surface malignancy following cancer resection were treated with intraperitoneal hyperthermic (41.5–42.5°C) cisplatin and doxorubicin combined with the infusion of systemic ifosfamide chemotherapy. The concentrations of ifosfamide and 4-hydroxyifosfamide were determined in plasma, peritoneal fluid, urine, and when possible, within small tumor nodules less than 1 cm. Plasma concentrations of ifosfamide exceeded peritoneal fluid levels of ifosfamide during the 90 minutes of chemotherapy infusion. Both ifosfamide and 4-hydroxyifosfamide could be recovered from peritoneal tumor nodules throughout the 90 minutes of ifosfamide continuous infusion and exceeded plasma concentrations. 4-Hydroxyifosfamide within peritoneal surface cancer nodules suggested a favorable pharmacologic endpoint in the study of ifosfamide administered in the operating room. Hindawi Publishing Corporation 2011 2011-09-21 /pmc/articles/PMC3263669/ /pubmed/22312496 http://dx.doi.org/10.1155/2011/185092 Text en Copyright © 2011 Kurt Van der Speeten et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Van der Speeten, Kurt
Stuart, O. Anthony
Mahteme, Haile
Sugarbaker, Paul H.
Pharmacokinetic Study of Perioperative Intravenous Ifosfamide
title Pharmacokinetic Study of Perioperative Intravenous Ifosfamide
title_full Pharmacokinetic Study of Perioperative Intravenous Ifosfamide
title_fullStr Pharmacokinetic Study of Perioperative Intravenous Ifosfamide
title_full_unstemmed Pharmacokinetic Study of Perioperative Intravenous Ifosfamide
title_short Pharmacokinetic Study of Perioperative Intravenous Ifosfamide
title_sort pharmacokinetic study of perioperative intravenous ifosfamide
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263669/
https://www.ncbi.nlm.nih.gov/pubmed/22312496
http://dx.doi.org/10.1155/2011/185092
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