Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review

Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) and BRCA2 genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management o...

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Detalles Bibliográficos
Autores principales: Bougie, O., Weberpals, J. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263675/
https://www.ncbi.nlm.nih.gov/pubmed/22312502
http://dx.doi.org/10.1155/2011/374012
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author Bougie, O.
Weberpals, J. I.
author_facet Bougie, O.
Weberpals, J. I.
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description Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) and BRCA2 genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management of mutation carriers. This review outlines salient aspects in the approach to patients at high risk of developing breast and ovarian cancer, including criteria for genetic testing, screening guidelines, surgical prophylaxis, and chemoprevention.
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spelling pubmed-32636752012-02-06 Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review Bougie, O. Weberpals, J. I. Int J Surg Oncol Review Article Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) and BRCA2 genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management of mutation carriers. This review outlines salient aspects in the approach to patients at high risk of developing breast and ovarian cancer, including criteria for genetic testing, screening guidelines, surgical prophylaxis, and chemoprevention. Hindawi Publishing Corporation 2011 2011-08-08 /pmc/articles/PMC3263675/ /pubmed/22312502 http://dx.doi.org/10.1155/2011/374012 Text en Copyright © 2011 O. Bougie and J. I. Weberpals. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bougie, O.
Weberpals, J. I.
Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
title Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
title_full Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
title_fullStr Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
title_full_unstemmed Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
title_short Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
title_sort clinical considerations of brca1- and brca2-mutation carriers: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263675/
https://www.ncbi.nlm.nih.gov/pubmed/22312502
http://dx.doi.org/10.1155/2011/374012
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