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Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs

We explored the potential for EXPAREL to interact with lidocaine. Sixty (60) male Yucatan Swine were randomized into 20 groups (N = 3/group). EXPAREL (2 or 4 mg/kg) and/or lidocaine HCl solution 1% or 2% (with epinephrine 1 : 200,000) were injected subcutaneously along a 5 cm virtual incision line....

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Autores principales: Richard, Brigitte M., Rickert, Douglas E., Doolittle, Dannette, Mize, Amy, Liu, Jason, Lawson, Charles F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263713/
https://www.ncbi.nlm.nih.gov/pubmed/22389853
http://dx.doi.org/10.5402/2011/582351
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author Richard, Brigitte M.
Rickert, Douglas E.
Doolittle, Dannette
Mize, Amy
Liu, Jason
Lawson, Charles F.
author_facet Richard, Brigitte M.
Rickert, Douglas E.
Doolittle, Dannette
Mize, Amy
Liu, Jason
Lawson, Charles F.
author_sort Richard, Brigitte M.
collection PubMed
description We explored the potential for EXPAREL to interact with lidocaine. Sixty (60) male Yucatan Swine were randomized into 20 groups (N = 3/group). EXPAREL (2 or 4 mg/kg) and/or lidocaine HCl solution 1% or 2% (with epinephrine 1 : 200,000) were injected subcutaneously along a 5 cm virtual incision line. The effects on the pharmacokinetics of bupivacaine and lidocaine were examined when 5, 10, 20, and 40 minutes had passed between administration of lidocaine and EXPAREL. Systemic exposure to lidocaine was increased (AUC(0−24 hr) by 48%; C (max) by 1,640%) when lidocaine (4 mg/kg) was followed 5 minutes later by EXPAREL (4 mg/kg) compared to lidocaine administered alone. Plasma bupivacaine was increased (AUC(0−24 hr) by 50–95%; C (max) by 67–1,000%) when lidocaine (4 mg/kg) was followed 5 or 10 minutes later by EXPAREL (4 mg/kg) compared to EXPAREL alone. While EXPAREL should not be admixed with lidocaine, this study shows that local administration of EXPAREL after at least 20 minutes following local administration of lidocaine did not increase the release of either drug.
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spelling pubmed-32637132012-03-02 Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs Richard, Brigitte M. Rickert, Douglas E. Doolittle, Dannette Mize, Amy Liu, Jason Lawson, Charles F. ISRN Pharm Research Article We explored the potential for EXPAREL to interact with lidocaine. Sixty (60) male Yucatan Swine were randomized into 20 groups (N = 3/group). EXPAREL (2 or 4 mg/kg) and/or lidocaine HCl solution 1% or 2% (with epinephrine 1 : 200,000) were injected subcutaneously along a 5 cm virtual incision line. The effects on the pharmacokinetics of bupivacaine and lidocaine were examined when 5, 10, 20, and 40 minutes had passed between administration of lidocaine and EXPAREL. Systemic exposure to lidocaine was increased (AUC(0−24 hr) by 48%; C (max) by 1,640%) when lidocaine (4 mg/kg) was followed 5 minutes later by EXPAREL (4 mg/kg) compared to lidocaine administered alone. Plasma bupivacaine was increased (AUC(0−24 hr) by 50–95%; C (max) by 67–1,000%) when lidocaine (4 mg/kg) was followed 5 or 10 minutes later by EXPAREL (4 mg/kg) compared to EXPAREL alone. While EXPAREL should not be admixed with lidocaine, this study shows that local administration of EXPAREL after at least 20 minutes following local administration of lidocaine did not increase the release of either drug. International Scholarly Research Network 2011 2011-12-27 /pmc/articles/PMC3263713/ /pubmed/22389853 http://dx.doi.org/10.5402/2011/582351 Text en Copyright © 2011 Brigitte M. Richard et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Richard, Brigitte M.
Rickert, Douglas E.
Doolittle, Dannette
Mize, Amy
Liu, Jason
Lawson, Charles F.
Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs
title Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs
title_full Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs
title_fullStr Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs
title_full_unstemmed Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs
title_short Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs
title_sort pharmacokinetic compatibility study of lidocaine with exparel in yucatan miniature pigs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263713/
https://www.ncbi.nlm.nih.gov/pubmed/22389853
http://dx.doi.org/10.5402/2011/582351
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