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Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer
Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biod...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263727/ https://www.ncbi.nlm.nih.gov/pubmed/22389852 http://dx.doi.org/10.5402/2011/578570 |
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author | Ibrahim, I. T. El-Tawoosy, M. Talaat, H. M. |
author_facet | Ibrahim, I. T. El-Tawoosy, M. Talaat, H. M. |
author_sort | Ibrahim, I. T. |
collection | PubMed |
description | Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biodistribution of (99m)Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of (99m)Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach. |
format | Online Article Text |
id | pubmed-3263727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-32637272012-03-02 Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer Ibrahim, I. T. El-Tawoosy, M. Talaat, H. M. ISRN Pharm Research Article Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biodistribution of (99m)Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of (99m)Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach. International Scholarly Research Network 2011 2011-07-19 /pmc/articles/PMC3263727/ /pubmed/22389852 http://dx.doi.org/10.5402/2011/578570 Text en Copyright © 2011 I. T. Ibrahim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ibrahim, I. T. El-Tawoosy, M. Talaat, H. M. Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer |
title | Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer |
title_full | Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer |
title_fullStr | Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer |
title_full_unstemmed | Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer |
title_short | Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer |
title_sort | labeling of tannic acid with technetium-99m for diagnosis of stomach ulcer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263727/ https://www.ncbi.nlm.nih.gov/pubmed/22389852 http://dx.doi.org/10.5402/2011/578570 |
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