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Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer

Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of  (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biod...

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Autores principales: Ibrahim, I. T., El-Tawoosy, M., Talaat, H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263727/
https://www.ncbi.nlm.nih.gov/pubmed/22389852
http://dx.doi.org/10.5402/2011/578570
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author Ibrahim, I. T.
El-Tawoosy, M.
Talaat, H. M.
author_facet Ibrahim, I. T.
El-Tawoosy, M.
Talaat, H. M.
author_sort Ibrahim, I. T.
collection PubMed
description Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of  (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biodistribution of (99m)Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of (99m)Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.
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spelling pubmed-32637272012-03-02 Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer Ibrahim, I. T. El-Tawoosy, M. Talaat, H. M. ISRN Pharm Research Article Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of  (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biodistribution of (99m)Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of (99m)Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach. International Scholarly Research Network 2011 2011-07-19 /pmc/articles/PMC3263727/ /pubmed/22389852 http://dx.doi.org/10.5402/2011/578570 Text en Copyright © 2011 I. T. Ibrahim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ibrahim, I. T.
El-Tawoosy, M.
Talaat, H. M.
Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer
title Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer
title_full Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer
title_fullStr Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer
title_full_unstemmed Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer
title_short Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer
title_sort labeling of tannic acid with technetium-99m for diagnosis of stomach ulcer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263727/
https://www.ncbi.nlm.nih.gov/pubmed/22389852
http://dx.doi.org/10.5402/2011/578570
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