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Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix
The present paper demonstrates the increased photostability of isotretinoin when loaded in microemulsion. The photodegradation of isotretinoin, in methanol and microemulsion formulation was studied under direct sun light. The photodegradation process was monitored by UV spectrophotometry. In methano...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263728/ https://www.ncbi.nlm.nih.gov/pubmed/22389863 http://dx.doi.org/10.5402/2011/838016 |
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author | Patel, Mrunali R. Patel, Rashmin B. Parikh, Jolly R. Patel, Bharat G. |
author_facet | Patel, Mrunali R. Patel, Rashmin B. Parikh, Jolly R. Patel, Bharat G. |
author_sort | Patel, Mrunali R. |
collection | PubMed |
description | The present paper demonstrates the increased photostability of isotretinoin when loaded in microemulsion. The photodegradation of isotretinoin, in methanol and microemulsion formulation was studied under direct sun light. The photodegradation process was monitored by UV spectrophotometry. In methanol solution, isotretinoin undergoes complete photodegradation just within a few minutes of light exposure. Isotretinoin incorporated in microemulsion formulation showed an increased stability in comparison to the methanol solutions. In particular for isotretinoin, a residual concentration of 75% was still present after a light irradiance versus a residual value of just 16% measured at the same time in methanol solution. Further, degradation kinetic parameters of isotretinoin-loaded microemulsion formulation were demonstrated increase isotretinoin half-life about five-times in comparison with a methanol solution under a direct sun light. |
format | Online Article Text |
id | pubmed-3263728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-32637282012-03-02 Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix Patel, Mrunali R. Patel, Rashmin B. Parikh, Jolly R. Patel, Bharat G. ISRN Pharm Research Article The present paper demonstrates the increased photostability of isotretinoin when loaded in microemulsion. The photodegradation of isotretinoin, in methanol and microemulsion formulation was studied under direct sun light. The photodegradation process was monitored by UV spectrophotometry. In methanol solution, isotretinoin undergoes complete photodegradation just within a few minutes of light exposure. Isotretinoin incorporated in microemulsion formulation showed an increased stability in comparison to the methanol solutions. In particular for isotretinoin, a residual concentration of 75% was still present after a light irradiance versus a residual value of just 16% measured at the same time in methanol solution. Further, degradation kinetic parameters of isotretinoin-loaded microemulsion formulation were demonstrated increase isotretinoin half-life about five-times in comparison with a methanol solution under a direct sun light. International Scholarly Research Network 2011 2011-07-14 /pmc/articles/PMC3263728/ /pubmed/22389863 http://dx.doi.org/10.5402/2011/838016 Text en Copyright © 2011 Mrunali R. Patel et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Patel, Mrunali R. Patel, Rashmin B. Parikh, Jolly R. Patel, Bharat G. Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix |
title | Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix |
title_full | Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix |
title_fullStr | Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix |
title_full_unstemmed | Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix |
title_short | Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix |
title_sort | improving the isotretinoin photostability by incorporating in microemulsion matrix |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263728/ https://www.ncbi.nlm.nih.gov/pubmed/22389863 http://dx.doi.org/10.5402/2011/838016 |
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