Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment

Objective. To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods. HIF-1α gene translation in active psoriatic lesions before and after 21-day treatment with capsaicin ointment was detected by in situ hybridization. Results. There was positive staining of HIF-1α gen...

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Autor principal: Yu, Chun-shui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263732/
https://www.ncbi.nlm.nih.gov/pubmed/22389862
http://dx.doi.org/10.5402/2011/821874
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author Yu, Chun-shui
author_facet Yu, Chun-shui
author_sort Yu, Chun-shui
collection PubMed
description Objective. To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods. HIF-1α gene translation in active psoriatic lesions before and after 21-day treatment with capsaicin ointment was detected by in situ hybridization. Results. There was positive staining of HIF-1α gene in all the layers of psoriatic epidermis (100.0%) before the treatment with capsaicin ointment, but the dyeing in epidermis were reduced obviously (22.2%) after the treatment for 21 days. Conclusion. HIF-1α gene translation in psoriatic epidermis was downregulated after capsaicin treatment for 21 days.
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spelling pubmed-32637322012-03-02 Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment Yu, Chun-shui ISRN Pharm Research Article Objective. To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods. HIF-1α gene translation in active psoriatic lesions before and after 21-day treatment with capsaicin ointment was detected by in situ hybridization. Results. There was positive staining of HIF-1α gene in all the layers of psoriatic epidermis (100.0%) before the treatment with capsaicin ointment, but the dyeing in epidermis were reduced obviously (22.2%) after the treatment for 21 days. Conclusion. HIF-1α gene translation in psoriatic epidermis was downregulated after capsaicin treatment for 21 days. International Scholarly Research Network 2011 2011-06-22 /pmc/articles/PMC3263732/ /pubmed/22389862 http://dx.doi.org/10.5402/2011/821874 Text en Copyright © 2011 Chun-shui Yu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yu, Chun-shui
Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment
title Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment
title_full Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment
title_fullStr Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment
title_full_unstemmed Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment
title_short Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment
title_sort study on hif-1α gene translation in psoriatic epidermis with the topical treatment of capsaicin ointment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263732/
https://www.ncbi.nlm.nih.gov/pubmed/22389862
http://dx.doi.org/10.5402/2011/821874
work_keys_str_mv AT yuchunshui studyonhif1agenetranslationinpsoriaticepidermiswiththetopicaltreatmentofcapsaicinointment

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