Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab

A 27-year-old woman was admitted for intractable right-sided neck, ear, and jaw pain with gradual development of tinnitus and hearing loss. A cerebral MRI showed meningo-dural enhancement, and additional diagnostic workup revealed a right pulmonary infiltrate and positive PR-3 ANCA. Biopsies from na...

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Autores principales: Just, Søren Andreas, Knudsen, John Bonde, Nielsen, Mie Kiszka, Junker, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263746/
https://www.ncbi.nlm.nih.gov/pubmed/22389798
http://dx.doi.org/10.5402/2011/608942
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author Just, Søren Andreas
Knudsen, John Bonde
Nielsen, Mie Kiszka
Junker, Peter
author_facet Just, Søren Andreas
Knudsen, John Bonde
Nielsen, Mie Kiszka
Junker, Peter
author_sort Just, Søren Andreas
collection PubMed
description A 27-year-old woman was admitted for intractable right-sided neck, ear, and jaw pain with gradual development of tinnitus and hearing loss. A cerebral MRI showed meningo-dural enhancement, and additional diagnostic workup revealed a right pulmonary infiltrate and positive PR-3 ANCA. Biopsies from nasal mucosa and lung showed chronic inflammation with granuloma formation. Based on these findings the patient was diagnosed with Wegener's granulomatosis with pachymeningitis. There was no clinical response to oral Prednisolone and Cyclophosphamide, but complete clinical and imaging remission was achieved by adding Rituximab.
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spelling pubmed-32637462012-03-02 Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab Just, Søren Andreas Knudsen, John Bonde Nielsen, Mie Kiszka Junker, Peter ISRN Rheumatol Case Report A 27-year-old woman was admitted for intractable right-sided neck, ear, and jaw pain with gradual development of tinnitus and hearing loss. A cerebral MRI showed meningo-dural enhancement, and additional diagnostic workup revealed a right pulmonary infiltrate and positive PR-3 ANCA. Biopsies from nasal mucosa and lung showed chronic inflammation with granuloma formation. Based on these findings the patient was diagnosed with Wegener's granulomatosis with pachymeningitis. There was no clinical response to oral Prednisolone and Cyclophosphamide, but complete clinical and imaging remission was achieved by adding Rituximab. International Scholarly Research Network 2011 2011-06-08 /pmc/articles/PMC3263746/ /pubmed/22389798 http://dx.doi.org/10.5402/2011/608942 Text en Copyright © 2011 Søren Andreas Just et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Just, Søren Andreas
Knudsen, John Bonde
Nielsen, Mie Kiszka
Junker, Peter
Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab
title Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab
title_full Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab
title_fullStr Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab
title_full_unstemmed Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab
title_short Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab
title_sort wegener's granulomatosis presenting with pachymeningitis: clinical and imaging remission by rituximab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263746/
https://www.ncbi.nlm.nih.gov/pubmed/22389798
http://dx.doi.org/10.5402/2011/608942
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