Variants in the SIRT1 Gene May Affect Diabetes Risk in Interaction With Prenatal Exposure to Famine

OBJECTIVE: To investigate whether SIRT1, a nutrient-sensing histone deacetylase, influences fetal programming during malnutrition. RESEARCH DESIGN AND METHODS: In 793 individuals of the Dutch Famine Birth Cohort, we analyzed the interaction between three SIRT1 single nucleotide polymorphisms (SNPs)...

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Detalles Bibliográficos
Autores principales: Botden, Ilse P.G., Zillikens, M. Carola, de Rooij, Susanne R., Langendonk, Janneke G., Danser, A.H. Jan, Sijbrands, Eric J.G., Roseboom, Tessa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263901/
https://www.ncbi.nlm.nih.gov/pubmed/22228742
http://dx.doi.org/10.2337/dc11-1203

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