Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity

BACKGROUND: Loss of GABA-mediated pre-synaptic inhibition after spinal injury plays a key role in the progressive increase in spinal reflexes and the appearance of spasticity. Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effective in modulating spasticity is assoc...

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Detalles Bibliográficos
Autores principales: Kakinohana, Osamu, Hefferan, Michael P., Miyanohara, Atsushi, Nejime, Tetsuya, Marsala, Silvia, Juhas, Stefan, Juhasova, Jana, Motlik, Jan, Kucharova, Karolina, Strnadel, Jan, Platoshyn, Oleksandr, Lazar, Peter, Galik, Jan, Vinay, Laurent, Marsala, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264568/
https://www.ncbi.nlm.nih.gov/pubmed/22291989
http://dx.doi.org/10.1371/journal.pone.0030561

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