Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis
Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and regulates food intake and energy expenditure....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264579/ https://www.ncbi.nlm.nih.gov/pubmed/22291999 http://dx.doi.org/10.1371/journal.pone.0030616 |
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author | Coupé, Bérengère Grit, Isabelle Hulin, Philippe Randuineau, Gwenaëlle Parnet, Patricia |
author_facet | Coupé, Bérengère Grit, Isabelle Hulin, Philippe Randuineau, Gwenaëlle Parnet, Patricia |
author_sort | Coupé, Bérengère |
collection | PubMed |
description | Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and regulates food intake and energy expenditure. Deficient leptin neuronal signalling favours weight gain by affecting central homeostatic circuitry. The aim of this study was to determine if leptin resistance was programmed by perinatal nutritional environment and to decipher potential cellular mechanisms underneath. We clearly demonstrated that 5 months old IUGR rats develop a decrease of leptin sentivity, characterized by no significant reduction of food intake following an intraperitoneal injection of leptin. Apart from the resistance to leptin injection, results obtained from IUGR rats submitted to rapid catch-up growth differed from those of IUGR rats with no catch-up since we observed, for the first group only, fat accumulation, increased appetite for food rich in fat and increased leptin synthesis. Centrally, the leptin resistant state of both groups was associated with a complex and not always similar changes in leptin receptor signalling steps. Leptin resistance in IUGR rats submitted to rapid catch-up was associated with alteration in AKT and mTOR pathways. Alternatively, in IUGR rats with no catch-up, leptin resistance was associated with low hypothalamic expression of LepRa and LepRb. This study reveals leptin resistance as an early marker of metabolic disorders that appears before any evidence of body weight increase in IUGR rats but whose mechanisms could depend of nutritional environment of the perinatal period. |
format | Online Article Text |
id | pubmed-3264579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32645792012-01-30 Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis Coupé, Bérengère Grit, Isabelle Hulin, Philippe Randuineau, Gwenaëlle Parnet, Patricia PLoS One Research Article Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and regulates food intake and energy expenditure. Deficient leptin neuronal signalling favours weight gain by affecting central homeostatic circuitry. The aim of this study was to determine if leptin resistance was programmed by perinatal nutritional environment and to decipher potential cellular mechanisms underneath. We clearly demonstrated that 5 months old IUGR rats develop a decrease of leptin sentivity, characterized by no significant reduction of food intake following an intraperitoneal injection of leptin. Apart from the resistance to leptin injection, results obtained from IUGR rats submitted to rapid catch-up growth differed from those of IUGR rats with no catch-up since we observed, for the first group only, fat accumulation, increased appetite for food rich in fat and increased leptin synthesis. Centrally, the leptin resistant state of both groups was associated with a complex and not always similar changes in leptin receptor signalling steps. Leptin resistance in IUGR rats submitted to rapid catch-up was associated with alteration in AKT and mTOR pathways. Alternatively, in IUGR rats with no catch-up, leptin resistance was associated with low hypothalamic expression of LepRa and LepRb. This study reveals leptin resistance as an early marker of metabolic disorders that appears before any evidence of body weight increase in IUGR rats but whose mechanisms could depend of nutritional environment of the perinatal period. Public Library of Science 2012-01-23 /pmc/articles/PMC3264579/ /pubmed/22291999 http://dx.doi.org/10.1371/journal.pone.0030616 Text en Coupé et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Coupé, Bérengère Grit, Isabelle Hulin, Philippe Randuineau, Gwenaëlle Parnet, Patricia Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis |
title | Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis |
title_full | Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis |
title_fullStr | Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis |
title_full_unstemmed | Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis |
title_short | Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis |
title_sort | postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264579/ https://www.ncbi.nlm.nih.gov/pubmed/22291999 http://dx.doi.org/10.1371/journal.pone.0030616 |
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