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Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastrointestinal tract. Despite FXR ligands are under investigation for treatment of cholestasis, a biochemical condition occurring in a number of liver diseases for which available therapies are poorly effec...

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Detalles Bibliográficos
Autores principales:	Renga, Barbara, Mencarelli, Andrea, D'Amore, Claudio, Cipriani, Sabrina, D'Auria, Maria Valeria, Sepe, Valentina, Chini, Maria Giovanna, Monti, Maria Chiara, Bifulco, Giuseppe, Zampella, Angela, Fiorucci, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264597/ https://www.ncbi.nlm.nih.gov/pubmed/22291955 http://dx.doi.org/10.1371/journal.pone.0030443

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