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eNOS Protects from Atherosclerosis Despite Relevant Superoxide Production by the Enzyme in apoE(−/−) Mice

BACKGROUND: All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation. Considering this alternative chemistr...

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Detalles Bibliográficos
Autores principales:	Ponnuswamy, Padmapriya, Schröttle, Angelika, Ostermeier, Eva, Grüner, Sabine, Huang, Paul L., Ertl, Georg, Hoffmann, Ulrich, Nieswandt, Bernhard, Kuhlencordt, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264598/ https://www.ncbi.nlm.nih.gov/pubmed/22291917 http://dx.doi.org/10.1371/journal.pone.0030193

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