Cargando…

The CD3-Zeta Chimeric Antigen Receptor Overcomes TCR Hypo-Responsiveness of Human Terminal Late-Stage T Cells

Adoptive therapy of malignant diseases with tumor-specific cytotoxic T cells showed remarkable efficacy in recent trials. Repetitive T cell receptor (TCR) engagement of target antigen, however, inevitably ends up in hypo-responsive cells with terminally differentiated KLRG-1(+) CD57(+) CD7(−) phenot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rappl, Gunter, Riet, Tobias, Awerkiew, Sabine, Schmidt, Annette, Hombach, Andreas A., Pfister, Herbert, Abken, Hinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264628/ https://www.ncbi.nlm.nih.gov/pubmed/22292024 http://dx.doi.org/10.1371/journal.pone.0030713

Ejemplares similares

Young T Cells Age During a Redirected Anti-Tumor Attack: Chimeric Antigen Receptor-Provided Dual Costimulation is Half the Battle
por: Hombach, Andreas A., et al.
Publicado: (2013)

Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells
por: Chmielewski, Markus, et al.
Publicado: (2013)

Chimeric antigen receptors designed to overcome transforming growth factor‐β‐mediated repression in the adoptive T‐cell therapy of solid tumors
por: Hartley, Jordan, et al.
Publicado: (2019)

IL12 integrated into the CAR exodomain converts CD8(+) T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors
por: Hombach, Andreas, et al.
Publicado: (2022)

Most Do, but Some Do Not: CD4(+)CD25(−) T Cells, but Not CD4(+)CD25(+) Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR)
por: Hombach, Andreas A., et al.
Publicado: (2017)

A Proteomic View at T Cell Costimulation
por: Lichtenfels, Rudolf, et al.
Publicado: (2012)

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit
Publicado: (1995)

Building on Synthetic Immunology and T Cell Engineering: A Brief Journey Through the History of Chimeric Antigen Receptors
por: Abken, Hinrich
Publicado: (2021)

OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T cells
por: Hombach, Andreas A., et al.
Publicado: (2012)

Do Treg Speed Up with CARs? Chimeric Antigen Receptor Treg Engineered to Induce Transplant Tolerance
por: Kaljanac, Marcell, et al.
Publicado: (2022)

Targeting two co-operating cytokines efficiently shapes immune responses
por: Hombach, Andreas A., et al.
Publicado: (2013)

CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation
por: Barden, Markus, et al.
Publicado: (2023)

Engineering T-cells with chimeric antigen receptors to combat hematological cancers: an update on clinical trials
por: Ormhøj, Maria, et al.
Publicado: (2022)

A TCR-based Chimeric Antigen Receptor
por: Walseng, Even, et al.
Publicado: (2017)

Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma
por: Skuljec, Jelena, et al.
Publicado: (2017)

Engineered T Cells for the Adoptive Therapy of B-Cell Chronic Lymphocytic Leukaemia
por: Koehler, Philipp, et al.
Publicado: (2012)

A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2(+) Solid Cancer
por: Hombach, Andreas A., et al.
Publicado: (2023)

Reduced Expression of TCR Zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus
por: Yoshimoto, Keiko, et al.
Publicado: (2010)

Zeta Functions over Zeros of Zeta Functions
por: Voros, Andre
Publicado: (2010)

PECAM1(+)/Sca1(+)/CD38(+) Vascular Cells Transform into Myofibroblast-Like Cells in Skin Wound Repair
por: Etich, Julia, et al.
Publicado: (2013)

FimH-based display of functional eukaryotic proteins on bacteria surfaces
por: Chmielewski, Markus, et al.
Publicado: (2019)

Improved Activation toward Primary Colorectal Cancer Cells by Antigen-Specific Targeting Autologous Cytokine-Induced Killer Cells
por: Schlimper, Claudia, et al.
Publicado: (2012)

IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells
por: Hombach, Andreas A., et al.
Publicado: (2020)

Zeta and q-Zeta Functions and Associated Series and Integrals
por: Srivastava, H M, et al.
Publicado: (2011)

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4(+) T cells to reduce the latent HIV(+) cell reservoir
por: Patasic, Lea, et al.
Publicado: (2020)

Zetas : la franquicia criminal /
por: Ravelo, Ricardo, 1966-

Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients
por: Taylor, D D, et al.
Publicado: (2001)

Hypo and Hyperthyroidism
por: Hixson, J. S.
Publicado: (1915)

An Il12-Il2-Antibody Fusion Protein Targeting Hodgkin's Lymphoma Cells Potentiates Activation Of Nk And T Cells For An Anti-Tumor Attack
por: Jahn, Tobias, et al.
Publicado: (2012)

The Riemann zeta-function
por: Karatsuba, Anatoly A, et al.
Publicado: (1992)

Riemann's zeta function
por: Edwards, Harold M
Publicado: (1974)

The Lerch zeta-function
por: Laurinčikas, Antanas, et al.
Publicado: (2002)

Shintani zeta functions
por: Yukie, Akihiko
Publicado: (1994)

The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth
por: Schmidt, Patrick, et al.
Publicado: (2011)

CAR T Cells: A Snapshot on the Growing Options to Design a CAR
por: Holzinger, Astrid, et al.
Publicado: (2019)

CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells
por: Thomas, Simone, et al.
Publicado: (2023)

Developmental arrest of NK1.1+ T cell antigen receptor (TCR)- alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice
Publicado: (1995)

Cases of Hypo-Thyroidism
por: Milne, C.
Publicado: (1914)

Hypo-Substitute for Opiates
Publicado: (1899)

Cannot write session to /tmp/vufind_sessions/sess_hp21s2b086vma2p20qk0thd6mi