TGFBR1 Intralocus Epistatic Interaction as a Risk Factor for Colorectal Cancer

In colorectal cancer (CRC), an inherited susceptibility risk affects about 35% of patients, whereas high-penetrance germline mutations account for <6% of cases. A considerable proportion of sporadic tumors could be explained by the coinheritance of multiple low-penetrance variants, some of which...

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Detalles Bibliográficos
Autores principales: Martinez-Canto, Ana, Castillejo, Adela, Mata-Balaguer, Trinidad, Castillejo, Maria-Isabel, Hernandez-Illan, Eva, Irles, Esperanza, Barbera, Victor Manuel, Egoavil, Cecilia, Guarinos, Carla, Alenda, Cristina, Ochoa, Enrique, Lazaro, Rafael, Fajardo, Silvia, Lacueva, Javier, Calpena, Rafael, Soto, Jose Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264637/
https://www.ncbi.nlm.nih.gov/pubmed/22292045
http://dx.doi.org/10.1371/journal.pone.0030812

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