Cargando…

AKT Signaling Mediates IGF-I Survival Actions on Otic Neural Progenitors

BACKGROUND: Otic neurons and sensory cells derive from common progenitors whose transition into mature cells requires the coordination of cell survival, proliferation and differentiation programmes. Neurotrophic support and survival of post-mitotic otic neurons have been intensively studied, but the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aburto, Maria R., Magariños, Marta, Leon, Yolanda, Varela-Nieto, Isabel, Sanchez-Calderon, Hortensia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264639/ https://www.ncbi.nlm.nih.gov/pubmed/22292041 http://dx.doi.org/10.1371/journal.pone.0030790

Ejemplares similares

Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation
por: León, Yolanda, et al.
Publicado: (2021)

Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation
por: Aburto, M R, et al.
Publicado: (2012)

Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner
por: Magariños, Marta, et al.
Publicado: (2020)

RAF Kinase Activity Regulates Neuroepithelial Cell Proliferation and Neuronal Progenitor Cell Differentiation during Early Inner Ear Development
por: Magariños, Marta, et al.
Publicado: (2010)

Autophagy During Vertebrate Development
por: Aburto, María R., et al.
Publicado: (2012)

RNA Microarray Analysis in Prenatal Mouse Cochlea Reveals Novel IGF-I Target Genes: Implication of MEF2 and FOXM1 Transcription Factors
por: Sanchez-Calderon, Hortensia, et al.
Publicado: (2010)

Autophagy in the Vertebrate Inner Ear
por: Magariños, Marta, et al.
Publicado: (2017)

Restoration of auditory evoked responses by human ES cell-derived otic progenitors
por: Chen, Wei, et al.
Publicado: (2012)

NEUROG1 Regulates CDK2 to Promote Proliferation in Otic Progenitors
por: Song, Zhichao, et al.
Publicado: (2017)

IGF-1 Controls Metabolic Homeostasis and Survival in HEI-OC1 Auditory Cells through AKT and mTOR Signaling
por: García-Mato, Ángela, et al.
Publicado: (2023)

Editorial: Aging, neurogenesis and neuroinflammation in hearing loss and protection
por: Magariños, Marta, et al.
Publicado: (2015)

TGFβ2-induced senescence during early inner ear development
por: Gibaja, Alejandro, et al.
Publicado: (2019)

Ophthalmic and Otic Memoranda
Publicado: (1877)

Enhanced survival of hypoimmunogenic otic progenitors following intracochlear xenotransplantation: repercussions for stem cell therapy in hearing loss models
por: Andrade da Silva, Luisa H., et al.
Publicado: (2023)

RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities
por: Maier, Esther C., et al.
Publicado: (2014)

Differentiation and transplantation of human induced pluripotent stem cell-derived otic epithelial progenitors in mouse cochlea
por: Chen, Jianling, et al.
Publicado: (2018)

Enriched Differentiation of Human Otic Sensory Progenitor Cells Derived From Induced Pluripotent Stem Cells
por: Lahlou, Hanae, et al.
Publicado: (2018)

Anatomical and Physiological Description of the Otic Ganglion
por: Tylee, William Salmon
Publicado: (1833)

Transplantation of Human Neural Progenitor Cells Expressing IGF-1 Enhances Retinal Ganglion Cell Survival
por: Ma, Jie, et al.
Publicado: (2015)

Sensational placodes: Neurogenesis in the otic and olfactory systems
por: Maier, Esther C., et al.
Publicado: (2014)

Origin of Neuroblasts in the Avian Otic Placode and Their Distributions in the Acoustic and Vestibular Ganglia
por: Hidalgo-Sánchez, Matías, et al.
Publicado: (2023)

C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells
por: Kwan, Kelvin Y., et al.
Publicado: (2014)

Regeneration of Hair Cells from Endogenous Otic Progenitors in the Adult Mammalian Cochlea: Understanding Its Origins and Future Directions
por: Smith-Cortinez, Natalia, et al.
Publicado: (2023)

Dysfunction of programmed embryo senescence is linked to genetic developmental defects
por: de Lope, Cristina, et al.
Publicado: (2023)

Induction of otic structures by canonical Wnt signalling in medaka
por: Bajoghli, Baubak, et al.
Publicado: (2009)

Identification and characterization of mouse otic sensory lineage genes
por: Hartman, Byron H., et al.
Publicado: (2015)

Enhancer activation by FGF signalling during otic induction
por: Tambalo, Monica, et al.
Publicado: (2020)

Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle
por: Matern, Maggie S., et al.
Publicado: (2023)

C-Raf deficiency leads to hearing loss and increased noise susceptibility
por: de Iriarte Rodríguez, Rocío, et al.
Publicado: (2015)

The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle
por: Kantarci, Husniye, et al.
Publicado: (2020)

IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes
por: Hsieh, Jenny, et al.
Publicado: (2004)

Efficacy and safety of fluocinolone acetonide 0.025% otic solution in patients with otic eczema: a randomized, double-blind, placebo-controlled clinical trial
por: Montoro, Victoria, et al.
Publicado: (2018)

IGF-1 enhances cell proliferation and survival during early differentiation of mesenchymal stem cells to neural progenitor-like cells
por: Huat, Tee Jong, et al.
Publicado: (2014)

Transcriptome-wide comparison of the impact of Atoh1 and miR-183 family on pluripotent stem cells and multipotent otic progenitor cells
por: Ebeid, Michael, et al.
Publicado: (2017)

Severe recalcitrant otic lichen planus treated with mycophenolate mofetil
por: Guo, Lisa N., et al.
Publicado: (2020)

Triangulation of pharmacoepidemiology and laboratory science to tackle otic quinolone safety
por: Winterstein, Almut G., et al.
Publicado: (2021)

LIF–IGF Axis Contributes to the Proliferation of Neural Progenitor Cells in Developing Rat Cerebrum
por: Takata, Sho, et al.
Publicado: (2022)

Bmi1 Loss in the Organ of Corti Results in p16(ink4a) Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro
por: Bassiouni, Mohamed, et al.
Publicado: (2016)

Analysis of FGF-Dependent and FGF-Independent Pathways in Otic Placode Induction
por: Yang, Lu, et al.
Publicado: (2013)

Ceruminal diffusion activities and ceruminolytic characteristics of otic preparations – an in-vitro study
por: Stahl, Jessica, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ci7tdlij79kn9lmm8hoeuds9k2