Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide

Centrally administered insulin-like growth factor (IGF)-I has anti-depressant activity in several rodent models, including lipopolysaccharide (LPS)-induced depression. In this study we tested the ability of IGF-I and GPE (the N-terminal tri-peptide derived from IGF-I) to alter depression-like behavi...

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Detalles Bibliográficos
Autores principales: Park, Sook-Eun, Lawson, Marcus, Dantzer, Robert, Kelley, Keith W, McCusker, Robert H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264674/
https://www.ncbi.nlm.nih.gov/pubmed/22189158
http://dx.doi.org/10.1186/1742-2094-8-179

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