Physicochemical and Biological Evaluation of siRNA Polyplexes Based on PEGylated Poly(amido amine)s

PURPOSE: Use of RNA interference as novel therapeutic strategy is hampered by inefficient delivery of its mediator, siRNA, to target cells. Cationic polymers have been thoroughly investigated for this purpose but often display unfavorable characteristics for systemic administration, such as interact...

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Detalles Bibliográficos
Autores principales: Vader, Pieter, van der Aa, Leonardus J., Engbersen, Johan F. J., Storm, Gert, Schiffelers, Raymond M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264854/
https://www.ncbi.nlm.nih.gov/pubmed/21833793
http://dx.doi.org/10.1007/s11095-011-0545-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264854/
https://www.ncbi.nlm.nih.gov/pubmed/21833793
http://dx.doi.org/10.1007/s11095-011-0545-z

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