In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions

PURPOSE: To establish in vitro and in silico models that predict clinical drug–drug interactions (DDIs) with the OATP1B1 (SLCO1B1) transporter. METHODS: The inhibitory effect of 146 drugs and drug-like compounds on OATP1B1-mediated transport was studied in HEK293 cells. A computational model was dev...

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Detalles Bibliográficos
Autores principales: Karlgren, Maria, Ahlin, Gustav, Bergström, Christel A. S., Svensson, Richard, Palm, Johan, Artursson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264873/
https://www.ncbi.nlm.nih.gov/pubmed/21861202
http://dx.doi.org/10.1007/s11095-011-0564-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264873/
https://www.ncbi.nlm.nih.gov/pubmed/21861202
http://dx.doi.org/10.1007/s11095-011-0564-9

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