Cargando…

Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility, High-Permeability Drug

PURPOSE: To demonstrate drug/polymer nanoparticles can increase the rate and extent of oral absorption of a low-solubility, high-permeability drug. METHODS: Amorphous drug/polymer nanoparticles containing celecoxib were prepared using ethyl cellulose and either sodium caseinate or bile salt. Nanopar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morgen, Michael, Bloom, Corey, Beyerinck, Ron, Bello, Akintunde, Song, Wei, Wilkinson, Karen, Steenwyk, Rick, Shamblin, Sheri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2011
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264876/ https://www.ncbi.nlm.nih.gov/pubmed/21863477 http://dx.doi.org/10.1007/s11095-011-0558-7

Ejemplares similares

Benzaldehyde, A New Absorption Promoter, Accelerating Absorption on Low Bioavailability Drugs Through Membrane Permeability
por: Wen, Wen, et al.
Publicado: (2021)

Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability: Experimental Approaches over In Vitro/In Vivo Evaluation
por: Arslan, Aslıhan, et al.
Publicado: (2023)

Self-Nanoemulsifying Drug Delivery Systems for Enhancing Solubility, Permeability, and Bioavailability of Sesamin
por: Wang, Chih-Yuan, et al.
Publicado: (2020)

Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability, Photostability, and Permeability
por: Giri, Bhupendra Raj, et al.
Publicado: (2022)

Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation
por: Zardán Gómez de la Torre, Teresa, et al.
Publicado: (2022)

Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib
por: Kim, Hye-In, et al.
Publicado: (2018)

Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition
por: Lee, Ju-Hyun, et al.
Publicado: (2021)

Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion
por: Shakeel, Faiyaz, et al.
Publicado: (2008)

Electrosprayed Polymeric Nanospheres for Enhanced Solubility, Dissolution Rate, Oral Bioavailability and Antihyperlipidemic Activity of Bezafibrate
por: Sun, Ru, et al.
Publicado: (2020)

Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles
por: B. Shekhawat, Prachi, et al.
Publicado: (2017)

Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs
por: Xu, Wei, et al.
Publicado: (2013)

Effect of Deep Eutectic System (DES) on Oral Bioavailability of Celecoxib: In Silico, In Vitro, and In Vivo Study
por: Chakraborty, Soumalya, et al.
Publicado: (2023)

Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
por: Jiang, Yihua, et al.
Publicado: (2022)

Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin
por: Umerska, Anita, et al.
Publicado: (2018)

The Effect of Food on Tramadol and Celecoxib Bioavailability Following Oral Administration of Co-Crystal of Tramadol–Celecoxib (CTC): A Randomised, Open-Label, Single-Dose, Crossover Study in Healthy Volunteers
por: Encina, Gregorio, et al.
Publicado: (2018)

Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique
por: Khames, Ahmed
Publicado: (2017)

Effect of Gastric Bypass Surgery on the Absorption and Bioavailability of Metformin
por: Padwal, Raj S., et al.
Publicado: (2011)

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil
por: Shen, Jin-Yang, et al.
Publicado: (2015)

Absolute bioavailability and regional absorption of ticagrelor in healthy volunteers
por: Teng, Renli, et al.
Publicado: (2014)

Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update
por: Schuchardt, Jan Philipp, et al.
Publicado: (2017)

Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight
por: Reboul, Emmanuelle
Publicado: (2017)

Cytokinesis-block micronucleus assay of celecoxib and celecoxib derivatives
por: Reimann, Hauke, et al.
Publicado: (2020)

Permeability Enhancers Dramatically Increase Zanamivir Absolute Bioavailability in Rats: Implications for an Orally Bioavailable Influenza Treatment
por: Holmes, Eric H., et al.
Publicado: (2013)

Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids
por: Park, Seyeon
Publicado: (2016)

Solubility and Bioavailability Enhancement of Oridonin: A Review
por: Zhang, Yuanyuan, et al.
Publicado: (2020)

Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
por: Shao, Huili, et al.
Publicado: (2021)

Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
por: Bolan, Shiv, et al.
Publicado: (2021)

An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides
por: Ghosh, Pritha, et al.
Publicado: (2023)

Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs
por: Delie, Florence, et al.
Publicado: (2005)

Development and mechanistic study of a microemulsion containing vitamin E TPGS for the enhancement of oral absorption of celecoxib
por: Subongkot, Thirapit
Publicado: (2019)

Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability
por: Lin, Hong-Liang, et al.
Publicado: (2021)

Absorption behavior of riociguat: bioavailability, food effects, and dose-proportionality
por: Becker, Corina, et al.
Publicado: (2013)

Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies
por: Datta-Mannan, Amita, et al.
Publicado: (2020)

The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin
por: Shen, Baode, et al.
Publicado: (2021)

Absorption and Bioavailability of Novel UltraShear Nanoemulsion of Cannabidiol in Rats
por: ElSohly, Mahmoud A., et al.
Publicado: (2023)

Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs
por: Censi, Roberta, et al.
Publicado: (2015)

Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin
por: Liu, Qian, et al.
Publicado: (2022)

Optimized solubility and bioavailability of genistein based on cocrystal engineering
por: Wang, Zhipeng, et al.
Publicado: (2023)

Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus)
por: Dhondt, Laura, et al.
Publicado: (2017)

Intestinal permeability, digestive stability and oral bioavailability of dietary small RNAs
por: Yang, Jian, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1si31rku6q7j402lrbs2ptl2sn