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Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer
The role of surgery in clinical stage T3 prostate cancer (cT3 PCa) is still subject to debate. We reviewed the records of 139 consecutive patients who underwent a radical prostatectomy (RP) for cT3 PCa with a mean follow-up of 8 years. All data related to surgical and perioperative complications wer...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265055/ https://www.ncbi.nlm.nih.gov/pubmed/22291698 http://dx.doi.org/10.1155/2012/706309 |
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author | Joniau, S. G. Van Baelen, A. A. Hsu, C. Y. Van Poppel, H. P. |
author_facet | Joniau, S. G. Van Baelen, A. A. Hsu, C. Y. Van Poppel, H. P. |
author_sort | Joniau, S. G. |
collection | PubMed |
description | The role of surgery in clinical stage T3 prostate cancer (cT3 PCa) is still subject to debate. We reviewed the records of 139 consecutive patients who underwent a radical prostatectomy (RP) for cT3 PCa with a mean follow-up of 8 years. All data related to surgical and perioperative complications were collected. Continence and erectile function were assessed at 12 months postoperatively and long-term oncologic outcomes were analyzed. Rectal injury and injury of the obturator nerve occurred both in 0.7% of cases. No serious in-hospital complications were noted and no reintervention was needed. Lymphatic leakage was noted in 2.2% of patients and 1.4% experienced prolonged drainage of urine. In 7.2%, wound-related problems occurred. Anastomotic stricture occurred in 2.9%. These complication rates were not different compared to surgical series of RP in localized PCa. At 12 months, complete continence was 87.8% and erectile function had fully recovered in 6% and 10% of patients who underwent a non-nerve sparing or unilateral nerve-sparing procedure, respectively. 10-year estimated biochemical PFS, clinical PFS, CSS and OS were 51.8%, 85.6%, 94.6% and 85.9%, respectively. In cT3 PCa, RP is technically feasible with morbidity comparable to RP in clinically localized PCa. Long-term oncologic control was excellent. |
format | Online Article Text |
id | pubmed-3265055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32650552012-01-30 Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer Joniau, S. G. Van Baelen, A. A. Hsu, C. Y. Van Poppel, H. P. Adv Urol Research Article The role of surgery in clinical stage T3 prostate cancer (cT3 PCa) is still subject to debate. We reviewed the records of 139 consecutive patients who underwent a radical prostatectomy (RP) for cT3 PCa with a mean follow-up of 8 years. All data related to surgical and perioperative complications were collected. Continence and erectile function were assessed at 12 months postoperatively and long-term oncologic outcomes were analyzed. Rectal injury and injury of the obturator nerve occurred both in 0.7% of cases. No serious in-hospital complications were noted and no reintervention was needed. Lymphatic leakage was noted in 2.2% of patients and 1.4% experienced prolonged drainage of urine. In 7.2%, wound-related problems occurred. Anastomotic stricture occurred in 2.9%. These complication rates were not different compared to surgical series of RP in localized PCa. At 12 months, complete continence was 87.8% and erectile function had fully recovered in 6% and 10% of patients who underwent a non-nerve sparing or unilateral nerve-sparing procedure, respectively. 10-year estimated biochemical PFS, clinical PFS, CSS and OS were 51.8%, 85.6%, 94.6% and 85.9%, respectively. In cT3 PCa, RP is technically feasible with morbidity comparable to RP in clinically localized PCa. Long-term oncologic control was excellent. Hindawi Publishing Corporation 2012 2012-01-12 /pmc/articles/PMC3265055/ /pubmed/22291698 http://dx.doi.org/10.1155/2012/706309 Text en Copyright © 2012 S. G. Joniau et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Joniau, S. G. Van Baelen, A. A. Hsu, C. Y. Van Poppel, H. P. Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer |
title | Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer |
title_full | Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer |
title_fullStr | Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer |
title_full_unstemmed | Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer |
title_short | Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer |
title_sort | complications and functional results of surgery for locally advanced prostate cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265055/ https://www.ncbi.nlm.nih.gov/pubmed/22291698 http://dx.doi.org/10.1155/2012/706309 |
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