The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.

The application of an HPLC bioactivity profiling/microtiter plate technique in conjunction with microprobe NMR instrumentation and access to the AntiMarin database has led to the isolation of a new 1. In this example, 1 was isolated from a cytotoxic fraction of an extract obtained from marine-derive...

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Autores principales: Mahyudin, Nor Ainy, Blunt, John W., Cole, Anthony L. J., Munro, Murray H. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265089/
https://www.ncbi.nlm.nih.gov/pubmed/22291452
http://dx.doi.org/10.1155/2012/894708
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author Mahyudin, Nor Ainy
Blunt, John W.
Cole, Anthony L. J.
Munro, Murray H. G.
author_facet Mahyudin, Nor Ainy
Blunt, John W.
Cole, Anthony L. J.
Munro, Murray H. G.
author_sort Mahyudin, Nor Ainy
collection PubMed
description The application of an HPLC bioactivity profiling/microtiter plate technique in conjunction with microprobe NMR instrumentation and access to the AntiMarin database has led to the isolation of a new 1. In this example, 1 was isolated from a cytotoxic fraction of an extract obtained from marine-derived Streptomyces sp. cultured on Starch Casein Agar (SCA) medium. The 1D and 2D (1)H NMR and ESIMS data obtained from 20 μg of compound 1 fully defined the structure. The known 2 was also isolated and readily dereplicated using this approach.
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spelling pubmed-32650892012-01-30 The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp. Mahyudin, Nor Ainy Blunt, John W. Cole, Anthony L. J. Munro, Murray H. G. J Biomed Biotechnol Research Article The application of an HPLC bioactivity profiling/microtiter plate technique in conjunction with microprobe NMR instrumentation and access to the AntiMarin database has led to the isolation of a new 1. In this example, 1 was isolated from a cytotoxic fraction of an extract obtained from marine-derived Streptomyces sp. cultured on Starch Casein Agar (SCA) medium. The 1D and 2D (1)H NMR and ESIMS data obtained from 20 μg of compound 1 fully defined the structure. The known 2 was also isolated and readily dereplicated using this approach. Hindawi Publishing Corporation 2012 2012-01-16 /pmc/articles/PMC3265089/ /pubmed/22291452 http://dx.doi.org/10.1155/2012/894708 Text en Copyright © 2012 Nor Ainy Mahyudin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mahyudin, Nor Ainy
Blunt, John W.
Cole, Anthony L. J.
Munro, Murray H. G.
The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.
title The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.
title_full The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.
title_fullStr The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.
title_full_unstemmed The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.
title_short The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.
title_sort isolation of a new s-methyl benzothioate compound from a marine-derived streptomyces sp.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265089/
https://www.ncbi.nlm.nih.gov/pubmed/22291452
http://dx.doi.org/10.1155/2012/894708
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