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Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients

Falls are a major source of disability in Parkinson's disease. Risk factors for falling in Parkinson's disease remain unclear. To determine the relevant risk factors for falling in Parkinson's disease, we screened 160 consecutive patients with Parkinson's disease for falls and as...

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Autores principales: Contreras, Ana, Grandas, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265111/
https://www.ncbi.nlm.nih.gov/pubmed/22292126
http://dx.doi.org/10.1155/2012/362572
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author Contreras, Ana
Grandas, Francisco
author_facet Contreras, Ana
Grandas, Francisco
author_sort Contreras, Ana
collection PubMed
description Falls are a major source of disability in Parkinson's disease. Risk factors for falling in Parkinson's disease remain unclear. To determine the relevant risk factors for falling in Parkinson's disease, we screened 160 consecutive patients with Parkinson's disease for falls and assessed 40 variables. A comparison between fallers and nonfallers was performed using statistical univariate analyses, followed by bivariate and multivariate logistic regression, receiver-operating characteristics analysis, and Kaplan-Meier curves. 38.8% of patients experienced falls since the onset of Parkinson's disease (recurrent in 67%). Tinetti Balance score and Hoehn and Yahr staging were the best independent variables associated with falls. The Tinetti Balance test predicted falls with 71% sensitivity and 79% specificity and Hoehn and Yahr staging with 77% sensitivity and 71% specificity. The risk of falls increased exponentially with age, especially from 70 years onward. Patients aged >70 years at the onset of Parkinson's disease experienced falls significantly earlier than younger patients.
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spelling pubmed-32651112012-01-30 Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients Contreras, Ana Grandas, Francisco Parkinsons Dis Clinical Study Falls are a major source of disability in Parkinson's disease. Risk factors for falling in Parkinson's disease remain unclear. To determine the relevant risk factors for falling in Parkinson's disease, we screened 160 consecutive patients with Parkinson's disease for falls and assessed 40 variables. A comparison between fallers and nonfallers was performed using statistical univariate analyses, followed by bivariate and multivariate logistic regression, receiver-operating characteristics analysis, and Kaplan-Meier curves. 38.8% of patients experienced falls since the onset of Parkinson's disease (recurrent in 67%). Tinetti Balance score and Hoehn and Yahr staging were the best independent variables associated with falls. The Tinetti Balance test predicted falls with 71% sensitivity and 79% specificity and Hoehn and Yahr staging with 77% sensitivity and 71% specificity. The risk of falls increased exponentially with age, especially from 70 years onward. Patients aged >70 years at the onset of Parkinson's disease experienced falls significantly earlier than younger patients. Hindawi Publishing Corporation 2012 2012-01-15 /pmc/articles/PMC3265111/ /pubmed/22292126 http://dx.doi.org/10.1155/2012/362572 Text en Copyright © 2012 A. Contreras and F. Grandas. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Contreras, Ana
Grandas, Francisco
Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients
title Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients
title_full Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients
title_fullStr Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients
title_full_unstemmed Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients
title_short Risk of Falls in Parkinson's Disease: A Cross-Sectional Study of 160 Patients
title_sort risk of falls in parkinson's disease: a cross-sectional study of 160 patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265111/
https://www.ncbi.nlm.nih.gov/pubmed/22292126
http://dx.doi.org/10.1155/2012/362572
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