Optimizing Liposomal Cisplatin Efficacy through Membrane Composition Manipulations

The first liposomal formulation of cisplatin to be evaluated clinically was SPI-077. Although the formulation demonstrated enhanced cisplatin tumor accumulation in preclinical models it did not enhance clinical efficacy, possibly due to limited cisplatin release from the formulation localized within...

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Detalles Bibliográficos
Autores principales: Zisman, Natalia, Dos Santos, Nancy, Johnstone, Sharon, Tsang, Alan, Bermudes, David, Mayer, Lawrence, Tardi, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265247/
https://www.ncbi.nlm.nih.gov/pubmed/22312548
http://dx.doi.org/10.1155/2011/213848

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