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Developing Central Nervous System and Vulnerability to Platinum Compounds
Comparative studies on the effects of the platinum complexes in use or in clinical trials are carried out in order to discover differences in the neurotoxic potential and the reversibility of neurotoxicity. In this paper, we summarized the current literature on neurotoxicity and chemoresistance of c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265252/ https://www.ncbi.nlm.nih.gov/pubmed/22312552 http://dx.doi.org/10.1155/2011/315418 |
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author | Bernocchi, G. Bottone, M. G. Piccolini, V. M. Dal Bo, V. Santin, G. De Pascali, S. A. Migoni, D. Fanizzi, F. P. |
author_facet | Bernocchi, G. Bottone, M. G. Piccolini, V. M. Dal Bo, V. Santin, G. De Pascali, S. A. Migoni, D. Fanizzi, F. P. |
author_sort | Bernocchi, G. |
collection | PubMed |
description | Comparative studies on the effects of the platinum complexes in use or in clinical trials are carried out in order to discover differences in the neurotoxic potential and the reversibility of neurotoxicity. In this paper, we summarized the current literature on neurotoxicity and chemoresistance of cisplatin (cisPt) and discussed our recent efforts on the interference of cisPt and a new platinum compound [Pt(O,O′-acac)(γ-acac)(DMS)] (PtAcacDMS), with high specific reactivity with sulphur ligands instead of nucleobases as cisPt, on some crucial events of rat postnatal cerebellum development. The acute effects of drug treatments on cell proliferation and death in the external granular layer and granule cell migration and the late effects on the dendrite growth of Purkinje cells were evaluated. Together with the demonstrated antineoplastic effectiveness in vitro, compared with cisPt, data suggest a lower neurotoxicity of PtAcacDMS, in spite of its presence in the brain that involves considerations on the blood brain barrier permeability. |
format | Online Article Text |
id | pubmed-3265252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32652522012-02-06 Developing Central Nervous System and Vulnerability to Platinum Compounds Bernocchi, G. Bottone, M. G. Piccolini, V. M. Dal Bo, V. Santin, G. De Pascali, S. A. Migoni, D. Fanizzi, F. P. Chemother Res Pract Review Article Comparative studies on the effects of the platinum complexes in use or in clinical trials are carried out in order to discover differences in the neurotoxic potential and the reversibility of neurotoxicity. In this paper, we summarized the current literature on neurotoxicity and chemoresistance of cisplatin (cisPt) and discussed our recent efforts on the interference of cisPt and a new platinum compound [Pt(O,O′-acac)(γ-acac)(DMS)] (PtAcacDMS), with high specific reactivity with sulphur ligands instead of nucleobases as cisPt, on some crucial events of rat postnatal cerebellum development. The acute effects of drug treatments on cell proliferation and death in the external granular layer and granule cell migration and the late effects on the dendrite growth of Purkinje cells were evaluated. Together with the demonstrated antineoplastic effectiveness in vitro, compared with cisPt, data suggest a lower neurotoxicity of PtAcacDMS, in spite of its presence in the brain that involves considerations on the blood brain barrier permeability. Hindawi Publishing Corporation 2011 2011-02-15 /pmc/articles/PMC3265252/ /pubmed/22312552 http://dx.doi.org/10.1155/2011/315418 Text en Copyright © 2011 G. Bernocchi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bernocchi, G. Bottone, M. G. Piccolini, V. M. Dal Bo, V. Santin, G. De Pascali, S. A. Migoni, D. Fanizzi, F. P. Developing Central Nervous System and Vulnerability to Platinum Compounds |
title | Developing Central Nervous System and Vulnerability to Platinum Compounds |
title_full | Developing Central Nervous System and Vulnerability to Platinum Compounds |
title_fullStr | Developing Central Nervous System and Vulnerability to Platinum Compounds |
title_full_unstemmed | Developing Central Nervous System and Vulnerability to Platinum Compounds |
title_short | Developing Central Nervous System and Vulnerability to Platinum Compounds |
title_sort | developing central nervous system and vulnerability to platinum compounds |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265252/ https://www.ncbi.nlm.nih.gov/pubmed/22312552 http://dx.doi.org/10.1155/2011/315418 |
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