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Lipoplatin Treatment in Lung and Breast Cancer
The introduction of cisplatin in cancer treatment represents an important achievement in the oncologic field. Many types of cancers are now treated with this drug, and in testicular cancer patients major results are reached. Since 1965, other compounds were disovered and among them carboplatin and o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265256/ https://www.ncbi.nlm.nih.gov/pubmed/22295201 http://dx.doi.org/10.1155/2011/125192 |
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author | Fantini, Manuela Gianni, Lorenzo Santelmo, Carlotta Drudi, Fabrizio Castellani, Cinzia Affatato, Alessandra Nicolini, Mario Ravaioli, Alberto |
author_facet | Fantini, Manuela Gianni, Lorenzo Santelmo, Carlotta Drudi, Fabrizio Castellani, Cinzia Affatato, Alessandra Nicolini, Mario Ravaioli, Alberto |
author_sort | Fantini, Manuela |
collection | PubMed |
description | The introduction of cisplatin in cancer treatment represents an important achievement in the oncologic field. Many types of cancers are now treated with this drug, and in testicular cancer patients major results are reached. Since 1965, other compounds were disovered and among them carboplatin and oxaliplatin are the main Cisplatin analogues showing similar clinical efficacy with a safer toxicity profile. Lipoplatin is a new liposomal cisplatin formulation which seems to have these characteristics. Lipoplatin was shown to be effective in NSCLC both in phase 2 and phase 3 trials, with the same response rate of Cisplatin, a comparable overall survival but less toxicity. A new protocol aiming to elucidate the double capacity of Lipoplatin to act as a chemotherapeutic and angiogenetic agent in triple-negative breast cancer patients is upcoming. |
format | Online Article Text |
id | pubmed-3265256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32652562012-01-31 Lipoplatin Treatment in Lung and Breast Cancer Fantini, Manuela Gianni, Lorenzo Santelmo, Carlotta Drudi, Fabrizio Castellani, Cinzia Affatato, Alessandra Nicolini, Mario Ravaioli, Alberto Chemother Res Pract Review Article The introduction of cisplatin in cancer treatment represents an important achievement in the oncologic field. Many types of cancers are now treated with this drug, and in testicular cancer patients major results are reached. Since 1965, other compounds were disovered and among them carboplatin and oxaliplatin are the main Cisplatin analogues showing similar clinical efficacy with a safer toxicity profile. Lipoplatin is a new liposomal cisplatin formulation which seems to have these characteristics. Lipoplatin was shown to be effective in NSCLC both in phase 2 and phase 3 trials, with the same response rate of Cisplatin, a comparable overall survival but less toxicity. A new protocol aiming to elucidate the double capacity of Lipoplatin to act as a chemotherapeutic and angiogenetic agent in triple-negative breast cancer patients is upcoming. Hindawi Publishing Corporation 2011 2010-12-21 /pmc/articles/PMC3265256/ /pubmed/22295201 http://dx.doi.org/10.1155/2011/125192 Text en Copyright © 2011 Manuela Fantini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fantini, Manuela Gianni, Lorenzo Santelmo, Carlotta Drudi, Fabrizio Castellani, Cinzia Affatato, Alessandra Nicolini, Mario Ravaioli, Alberto Lipoplatin Treatment in Lung and Breast Cancer |
title | Lipoplatin Treatment in Lung and Breast Cancer |
title_full | Lipoplatin Treatment in Lung and Breast Cancer |
title_fullStr | Lipoplatin Treatment in Lung and Breast Cancer |
title_full_unstemmed | Lipoplatin Treatment in Lung and Breast Cancer |
title_short | Lipoplatin Treatment in Lung and Breast Cancer |
title_sort | lipoplatin treatment in lung and breast cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265256/ https://www.ncbi.nlm.nih.gov/pubmed/22295201 http://dx.doi.org/10.1155/2011/125192 |
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