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XMRV Discovery and Prostate Cancer-Related Research

Xenotropic murine leukemia virus-related virus (XMRV) was first reported in 2006 in a study of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L. Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in...

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Autores principales: Kang, David E., Lee, Michael C., Das Gupta, Jaydip, Klein, Eric A., Silverman, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265305/
https://www.ncbi.nlm.nih.gov/pubmed/22312343
http://dx.doi.org/10.1155/2011/432837
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author Kang, David E.
Lee, Michael C.
Das Gupta, Jaydip
Klein, Eric A.
Silverman, Robert H.
author_facet Kang, David E.
Lee, Michael C.
Das Gupta, Jaydip
Klein, Eric A.
Silverman, Robert H.
author_sort Kang, David E.
collection PubMed
description Xenotropic murine leukemia virus-related virus (XMRV) was first reported in 2006 in a study of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L. Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in patients (prostate cancer, chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), and immunosuppressed with respiratory tract infections) or normal, healthy, control individuals. The principal confounding factors are the near ubiquitous presence of mouse-derived reagents, antibodies and cells, and often XMRV itself, in laboratories. XMRV infects and replicates well in many human cell lines, but especially in certain prostate cancer cell lines. XMRV also traffics to prostate in a nonhuman primate model of infection. Here, we will review the discovery of XMRV and then focus on prostate cancer-related research involving this intriguing virus.
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spelling pubmed-32653052012-02-06 XMRV Discovery and Prostate Cancer-Related Research Kang, David E. Lee, Michael C. Das Gupta, Jaydip Klein, Eric A. Silverman, Robert H. Adv Virol Review Article Xenotropic murine leukemia virus-related virus (XMRV) was first reported in 2006 in a study of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L. Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in patients (prostate cancer, chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), and immunosuppressed with respiratory tract infections) or normal, healthy, control individuals. The principal confounding factors are the near ubiquitous presence of mouse-derived reagents, antibodies and cells, and often XMRV itself, in laboratories. XMRV infects and replicates well in many human cell lines, but especially in certain prostate cancer cell lines. XMRV also traffics to prostate in a nonhuman primate model of infection. Here, we will review the discovery of XMRV and then focus on prostate cancer-related research involving this intriguing virus. Hindawi Publishing Corporation 2011 2011-06-21 /pmc/articles/PMC3265305/ /pubmed/22312343 http://dx.doi.org/10.1155/2011/432837 Text en Copyright © 2011 David E. Kang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kang, David E.
Lee, Michael C.
Das Gupta, Jaydip
Klein, Eric A.
Silverman, Robert H.
XMRV Discovery and Prostate Cancer-Related Research
title XMRV Discovery and Prostate Cancer-Related Research
title_full XMRV Discovery and Prostate Cancer-Related Research
title_fullStr XMRV Discovery and Prostate Cancer-Related Research
title_full_unstemmed XMRV Discovery and Prostate Cancer-Related Research
title_short XMRV Discovery and Prostate Cancer-Related Research
title_sort xmrv discovery and prostate cancer-related research
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265305/
https://www.ncbi.nlm.nih.gov/pubmed/22312343
http://dx.doi.org/10.1155/2011/432837
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