Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples

Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, w...

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Detalles Bibliográficos
Autores principales: Cingöz, Oya, Coffin, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265319/
https://www.ncbi.nlm.nih.gov/pubmed/22312358
http://dx.doi.org/10.1155/2011/940210
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author Cingöz, Oya
Coffin, John M.
author_facet Cingöz, Oya
Coffin, John M.
author_sort Cingöz, Oya
collection PubMed
description Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, we review the relationship of the human and mouse virus isolates and discuss the potential complications associated with the detection of MLV-like sequences from clinical samples.
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spelling pubmed-32653192012-02-06 Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples Cingöz, Oya Coffin, John M. Adv Virol Review Article Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, we review the relationship of the human and mouse virus isolates and discuss the potential complications associated with the detection of MLV-like sequences from clinical samples. Hindawi Publishing Corporation 2011 2011-10-24 /pmc/articles/PMC3265319/ /pubmed/22312358 http://dx.doi.org/10.1155/2011/940210 Text en Copyright © 2011 O. Cingöz and J. M. Coffin. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cingöz, Oya
Coffin, John M.
Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
title Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
title_full Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
title_fullStr Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
title_full_unstemmed Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
title_short Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
title_sort endogenous murine leukemia viruses: relationship to xmrv and related sequences detected in human dna samples
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265319/
https://www.ncbi.nlm.nih.gov/pubmed/22312358
http://dx.doi.org/10.1155/2011/940210
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