Cargando…
Sexual Transmission of XMRV: A Potential Infection Route
Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, al...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265321/ https://www.ncbi.nlm.nih.gov/pubmed/22312360 http://dx.doi.org/10.1155/2011/965689 |
_version_ | 1782222073805930496 |
---|---|
author | Sharma, Prachi Rogers, Kenneth A. Suppiah, Suganthi Molinaro, Ross J. Onlamoon, Nattawat Hackett, John Schochetman, Gerald Klein, Eric A. Silverman, Robert H. Villinger, François |
author_facet | Sharma, Prachi Rogers, Kenneth A. Suppiah, Suganthi Molinaro, Ross J. Onlamoon, Nattawat Hackett, John Schochetman, Gerald Klein, Eric A. Silverman, Robert H. Villinger, François |
author_sort | Sharma, Prachi |
collection | PubMed |
description | Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, all infected macaques exhibited readily detectable XMRV signal in the reproductive tract of all 4 males and 1 female during both acute and chronic infection stages. XMRV showed explosive growth in the acini of prostate during acute but not chronic infection. In seminal vesicles, epididymis, and testes, XMRV protein production was detected throughout infection in interstitial or epithelial cells. In the female monkey, epithelial cells in the cervix and vagina were also positive for XMRV gag. The ready detection of XMRV in the reproductive tract of male and female macaques infected intravenously suggests the potential for sexual transmission for XMRV. |
format | Online Article Text |
id | pubmed-3265321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32653212012-02-06 Sexual Transmission of XMRV: A Potential Infection Route Sharma, Prachi Rogers, Kenneth A. Suppiah, Suganthi Molinaro, Ross J. Onlamoon, Nattawat Hackett, John Schochetman, Gerald Klein, Eric A. Silverman, Robert H. Villinger, François Adv Virol Research Article Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, all infected macaques exhibited readily detectable XMRV signal in the reproductive tract of all 4 males and 1 female during both acute and chronic infection stages. XMRV showed explosive growth in the acini of prostate during acute but not chronic infection. In seminal vesicles, epididymis, and testes, XMRV protein production was detected throughout infection in interstitial or epithelial cells. In the female monkey, epithelial cells in the cervix and vagina were also positive for XMRV gag. The ready detection of XMRV in the reproductive tract of male and female macaques infected intravenously suggests the potential for sexual transmission for XMRV. Hindawi Publishing Corporation 2011 2011-07-24 /pmc/articles/PMC3265321/ /pubmed/22312360 http://dx.doi.org/10.1155/2011/965689 Text en Copyright © 2011 Prachi Sharma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sharma, Prachi Rogers, Kenneth A. Suppiah, Suganthi Molinaro, Ross J. Onlamoon, Nattawat Hackett, John Schochetman, Gerald Klein, Eric A. Silverman, Robert H. Villinger, François Sexual Transmission of XMRV: A Potential Infection Route |
title | Sexual Transmission of XMRV: A Potential Infection Route |
title_full | Sexual Transmission of XMRV: A Potential Infection Route |
title_fullStr | Sexual Transmission of XMRV: A Potential Infection Route |
title_full_unstemmed | Sexual Transmission of XMRV: A Potential Infection Route |
title_short | Sexual Transmission of XMRV: A Potential Infection Route |
title_sort | sexual transmission of xmrv: a potential infection route |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265321/ https://www.ncbi.nlm.nih.gov/pubmed/22312360 http://dx.doi.org/10.1155/2011/965689 |
work_keys_str_mv | AT sharmaprachi sexualtransmissionofxmrvapotentialinfectionroute AT rogerskennetha sexualtransmissionofxmrvapotentialinfectionroute AT suppiahsuganthi sexualtransmissionofxmrvapotentialinfectionroute AT molinarorossj sexualtransmissionofxmrvapotentialinfectionroute AT onlamoonnattawat sexualtransmissionofxmrvapotentialinfectionroute AT hackettjohn sexualtransmissionofxmrvapotentialinfectionroute AT schochetmangerald sexualtransmissionofxmrvapotentialinfectionroute AT kleinerica sexualtransmissionofxmrvapotentialinfectionroute AT silvermanroberth sexualtransmissionofxmrvapotentialinfectionroute AT villingerfrancois sexualtransmissionofxmrvapotentialinfectionroute |