Plasmid-Cured Chlamydia caviae Activates TLR2-Dependent Signaling and Retains Virulence in the Guinea Pig Model of Genital Tract Infection

Loss of the conserved “cryptic” plasmid from C. trachomatis and C. muridarum is pleiotropic, resulting in reduced innate inflammatory activation via TLR2, glycogen accumulation and infectivity. The more genetically distant C. caviae GPIC is a natural pathogen of guinea pigs and induces upper genital...

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Detalles Bibliográficos
Autores principales: Frazer, Lauren C., Darville, Toni, Chandra-Kuntal, Kumar, Andrews, Charles W., Zurenski, Matthew, Mintus, Margaret, AbdelRahman, Yasser M., Belland, Robert J., Ingalls, Robin R., O'Connell, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265510/
https://www.ncbi.nlm.nih.gov/pubmed/22292031
http://dx.doi.org/10.1371/journal.pone.0030747

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