Beltless Translocation Domain of Botulinum Neurotoxin A Embodies a Minimum Ion-conductive Channel

Botulinum neurotoxin, the causative agent of the paralytic disease botulism, is an endopeptidase composed of a catalytic domain (or light chain (LC)) and a heavy chain (HC) encompassing the translocation domain (TD) and receptor-binding domain. Upon receptor-mediated endocytosis, the LC and TD are p...

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Detalles Bibliográficos
Autores principales: Fischer, Audrey, Sambashivan, Shilpa, Brunger, Axel T., Montal, Mauricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265847/
https://www.ncbi.nlm.nih.gov/pubmed/22158863
http://dx.doi.org/10.1074/jbc.C111.319400

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