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The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265948/ https://www.ncbi.nlm.nih.gov/pubmed/22270915 http://dx.doi.org/10.1083/jcb.201103008 |
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author | Rojas, Ana Maria Fuentes, Gloria Rausell, Antonio Valencia, Alfonso |
author_facet | Rojas, Ana Maria Fuentes, Gloria Rausell, Antonio Valencia, Alfonso |
author_sort | Rojas, Ana Maria |
collection | PubMed |
description | The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex relationships between the evolution of this protein superfamily sequence and the acquisition of distinct cellular functions. Together with advances in computational methods and structural studies, the sequence information has helped to identify features important for the recognition of molecular partners and the functional specialization of different members of the Ras superfamily. |
format | Online Article Text |
id | pubmed-3265948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32659482012-07-23 The Ras protein superfamily: Evolutionary tree and role of conserved amino acids Rojas, Ana Maria Fuentes, Gloria Rausell, Antonio Valencia, Alfonso J Cell Biol Reviews The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex relationships between the evolution of this protein superfamily sequence and the acquisition of distinct cellular functions. Together with advances in computational methods and structural studies, the sequence information has helped to identify features important for the recognition of molecular partners and the functional specialization of different members of the Ras superfamily. The Rockefeller University Press 2012-01-23 /pmc/articles/PMC3265948/ /pubmed/22270915 http://dx.doi.org/10.1083/jcb.201103008 Text en © 2012 Rojas et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Rojas, Ana Maria Fuentes, Gloria Rausell, Antonio Valencia, Alfonso The Ras protein superfamily: Evolutionary tree and role of conserved amino acids |
title | The Ras protein superfamily: Evolutionary tree and role of conserved amino acids |
title_full | The Ras protein superfamily: Evolutionary tree and role of conserved amino acids |
title_fullStr | The Ras protein superfamily: Evolutionary tree and role of conserved amino acids |
title_full_unstemmed | The Ras protein superfamily: Evolutionary tree and role of conserved amino acids |
title_short | The Ras protein superfamily: Evolutionary tree and role of conserved amino acids |
title_sort | ras protein superfamily: evolutionary tree and role of conserved amino acids |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265948/ https://www.ncbi.nlm.nih.gov/pubmed/22270915 http://dx.doi.org/10.1083/jcb.201103008 |
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