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The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the...

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Detalles Bibliográficos
Autores principales: Rojas, Ana Maria, Fuentes, Gloria, Rausell, Antonio, Valencia, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265948/
https://www.ncbi.nlm.nih.gov/pubmed/22270915
http://dx.doi.org/10.1083/jcb.201103008
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author Rojas, Ana Maria
Fuentes, Gloria
Rausell, Antonio
Valencia, Alfonso
author_facet Rojas, Ana Maria
Fuentes, Gloria
Rausell, Antonio
Valencia, Alfonso
author_sort Rojas, Ana Maria
collection PubMed
description The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex relationships between the evolution of this protein superfamily sequence and the acquisition of distinct cellular functions. Together with advances in computational methods and structural studies, the sequence information has helped to identify features important for the recognition of molecular partners and the functional specialization of different members of the Ras superfamily.
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spelling pubmed-32659482012-07-23 The Ras protein superfamily: Evolutionary tree and role of conserved amino acids Rojas, Ana Maria Fuentes, Gloria Rausell, Antonio Valencia, Alfonso J Cell Biol Reviews The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex relationships between the evolution of this protein superfamily sequence and the acquisition of distinct cellular functions. Together with advances in computational methods and structural studies, the sequence information has helped to identify features important for the recognition of molecular partners and the functional specialization of different members of the Ras superfamily. The Rockefeller University Press 2012-01-23 /pmc/articles/PMC3265948/ /pubmed/22270915 http://dx.doi.org/10.1083/jcb.201103008 Text en © 2012 Rojas et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Rojas, Ana Maria
Fuentes, Gloria
Rausell, Antonio
Valencia, Alfonso
The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
title The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
title_full The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
title_fullStr The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
title_full_unstemmed The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
title_short The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
title_sort ras protein superfamily: evolutionary tree and role of conserved amino acids
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265948/
https://www.ncbi.nlm.nih.gov/pubmed/22270915
http://dx.doi.org/10.1083/jcb.201103008
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