FAK and talin: Who is taking whom to the integrin engagement party?

In this issue, Lawson et al. provide new insight into the relationship between FAK and talin during assembly of integrin adhesions on fibronectin. They show that FAK is upstream of talin, and that talin is not required for FAK recruitment or for integrin activation at nascent adhesions. However, FAK...

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Detalles Bibliográficos
Autores principales: Serrels, Bryan, Frame, Margaret C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265951/
https://www.ncbi.nlm.nih.gov/pubmed/22270914
http://dx.doi.org/10.1083/jcb.201112128
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author Serrels, Bryan
Frame, Margaret C.
author_facet Serrels, Bryan
Frame, Margaret C.
author_sort Serrels, Bryan
collection PubMed
description In this issue, Lawson et al. provide new insight into the relationship between FAK and talin during assembly of integrin adhesions on fibronectin. They show that FAK is upstream of talin, and that talin is not required for FAK recruitment or for integrin activation at nascent adhesions. However, FAK-talin binding is required for adhesion turnover and cell motility. The findings question the view that talin is always upstream of focal adhesion protein recruitment to clustered integrin sites.
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spelling pubmed-32659512012-07-23 FAK and talin: Who is taking whom to the integrin engagement party? Serrels, Bryan Frame, Margaret C. J Cell Biol Reviews In this issue, Lawson et al. provide new insight into the relationship between FAK and talin during assembly of integrin adhesions on fibronectin. They show that FAK is upstream of talin, and that talin is not required for FAK recruitment or for integrin activation at nascent adhesions. However, FAK-talin binding is required for adhesion turnover and cell motility. The findings question the view that talin is always upstream of focal adhesion protein recruitment to clustered integrin sites. The Rockefeller University Press 2012-01-23 /pmc/articles/PMC3265951/ /pubmed/22270914 http://dx.doi.org/10.1083/jcb.201112128 Text en © 2012 Serrels and Frame This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Serrels, Bryan
Frame, Margaret C.
FAK and talin: Who is taking whom to the integrin engagement party?
title FAK and talin: Who is taking whom to the integrin engagement party?
title_full FAK and talin: Who is taking whom to the integrin engagement party?
title_fullStr FAK and talin: Who is taking whom to the integrin engagement party?
title_full_unstemmed FAK and talin: Who is taking whom to the integrin engagement party?
title_short FAK and talin: Who is taking whom to the integrin engagement party?
title_sort fak and talin: who is taking whom to the integrin engagement party?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265951/
https://www.ncbi.nlm.nih.gov/pubmed/22270914
http://dx.doi.org/10.1083/jcb.201112128
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