The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous

In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers...

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Detalles Bibliográficos
Autores principales: Imwong, Mallika, Boel, Machteld E., Pagornrat, Watcharee, Pimanpanarak, Mupawjay, McGready, Rose, Day, Nicholas P. J., Nosten, François, White, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266132/
https://www.ncbi.nlm.nih.gov/pubmed/22194628
http://dx.doi.org/10.1093/infdis/jir806
Descripción
Sumario:In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to the initial infection in 13 of 20 (65%) mothers compared with 5 of 24 (21%) infants (P = .02). The first P. vivax relapses of life are usually genetically homologous, whereas relapse in adults may result from activation of heterologous latent hypnozoites acquired from previous inoculations.

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