The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous

In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers...

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Autores principales: Imwong, Mallika, Boel, Machteld E., Pagornrat, Watcharee, Pimanpanarak, Mupawjay, McGready, Rose, Day, Nicholas P. J., Nosten, François, White, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266132/
https://www.ncbi.nlm.nih.gov/pubmed/22194628
http://dx.doi.org/10.1093/infdis/jir806
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author Imwong, Mallika
Boel, Machteld E.
Pagornrat, Watcharee
Pimanpanarak, Mupawjay
McGready, Rose
Day, Nicholas P. J.
Nosten, François
White, Nicholas J.
author_facet Imwong, Mallika
Boel, Machteld E.
Pagornrat, Watcharee
Pimanpanarak, Mupawjay
McGready, Rose
Day, Nicholas P. J.
Nosten, François
White, Nicholas J.
author_sort Imwong, Mallika
collection PubMed
description In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to the initial infection in 13 of 20 (65%) mothers compared with 5 of 24 (21%) infants (P = .02). The first P. vivax relapses of life are usually genetically homologous, whereas relapse in adults may result from activation of heterologous latent hypnozoites acquired from previous inoculations.
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spelling pubmed-32661322012-01-25 The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous Imwong, Mallika Boel, Machteld E. Pagornrat, Watcharee Pimanpanarak, Mupawjay McGready, Rose Day, Nicholas P. J. Nosten, François White, Nicholas J. J Infect Dis Major Articles and Brief Reports In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to the initial infection in 13 of 20 (65%) mothers compared with 5 of 24 (21%) infants (P = .02). The first P. vivax relapses of life are usually genetically homologous, whereas relapse in adults may result from activation of heterologous latent hypnozoites acquired from previous inoculations. Oxford University Press 2012-02-15 2011-12-22 /pmc/articles/PMC3266132/ /pubmed/22194628 http://dx.doi.org/10.1093/infdis/jir806 Text en © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Imwong, Mallika
Boel, Machteld E.
Pagornrat, Watcharee
Pimanpanarak, Mupawjay
McGready, Rose
Day, Nicholas P. J.
Nosten, François
White, Nicholas J.
The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous
title The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous
title_full The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous
title_fullStr The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous
title_full_unstemmed The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous
title_short The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous
title_sort first plasmodium vivax relapses of life are usually genetically homologous
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266132/
https://www.ncbi.nlm.nih.gov/pubmed/22194628
http://dx.doi.org/10.1093/infdis/jir806
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