Protein dynamics and conformational selection in bidirectional signal transduction

Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways....

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Detalles Bibliográficos
Autores principales: Nussinov, Ruth, Ma, Buyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266202/
https://www.ncbi.nlm.nih.gov/pubmed/22277130
http://dx.doi.org/10.1186/1741-7007-10-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266202/
https://www.ncbi.nlm.nih.gov/pubmed/22277130
http://dx.doi.org/10.1186/1741-7007-10-2

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