Cargando…

LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease

BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) involves steatosis combined with inflammation, which can progress into fibrosis and cirrhosis. Exploring the molecular mechanisms of NASH is highly dependent on the availability of animal models. Currently, the most commonly used animal mod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bieghs, Veerle, Van Gorp, Patrick J., Wouters, Kristiaan, Hendrikx, Tim, Gijbels, Marion J., van Bilsen, Marc, Bakker, Jaap, Binder, Christoph J., Lütjohann, Dieter, Staels, Bart, Hofker, Marten H., Shiri-Sverdlov, Ronit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266276/ https://www.ncbi.nlm.nih.gov/pubmed/22295101 http://dx.doi.org/10.1371/journal.pone.0030668

Ejemplares similares

Internalization of Modified Lipids by CD36 and SR-A Leads to Hepatic Inflammation and Lysosomal Cholesterol Storage in Kupffer Cells
por: Bieghs, Veerle, et al.
Publicado: (2012)

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation
por: Houben, Tom, et al.
Publicado: (2017)

Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice
por: Hendrikx, Tim, et al.
Publicado: (2013)

Cathepsin D regulates lipid metabolism in murine steatohepatitis
por: Houben, Tom, et al.
Publicado: (2017)

Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice
por: Rensen, Sander S., et al.
Publicado: (2012)

Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice
por: Walenbergh, Sofie M. A., et al.
Publicado: (2015)

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention
por: Walenbergh, Sofie M. A., et al.
Publicado: (2016)

Oxidized LDL in Inflammation: From Bench to Bedside
por: Tekin, Ishak Ozel, et al.
Publicado: (2013)

Anti-Inflammatory Effects of Dietary Plant Stanol Supplementation Are Largely Dependent on the Intake of Cholesterol in a Mouse Model of Metabolic Inflammation
por: Magro dos Reis, Inês, et al.
Publicado: (2021)

Protective Role of Plant Sterol and Stanol Esters in Liver Inflammation: Insights from Mice and Humans
por: Plat, Jogchum, et al.
Publicado: (2014)

Cholesterol-Induced Hepatic Inflammation Does Not Underlie the Predisposition to Insulin Resistance in Dyslipidemic Female LDL Receptor Knockout Mice
por: Gruben, Nanda, et al.
Publicado: (2015)

Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women
por: van Vliet-Ostaptchouk, Jana V., et al.
Publicado: (2008)

Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease
por: Houben, Tom, et al.
Publicado: (2019)

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr(-/-) Mice
por: Jeurissen, Mike L. J., et al.
Publicado: (2016)

Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment
por: Houben, Tom, et al.
Publicado: (2021)

Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease
por: Hendrikx, Tim, et al.
Publicado: (2016)

Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model
por: Li, Jieyi, et al.
Publicado: (2016)

Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice
por: Yadati, Tulasi, et al.
Publicado: (2021)

OxLDL as an Inducer of a Metabolic Shift in Cancer Cells
por: Bitorina, Albert V., et al.
Publicado: (2021)

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells
por: Gruber, Sabrina, et al.
Publicado: (2016)

Hematopoietic Npc1 mutation shifts gut microbiota composition in Ldlr(−/−) mice on a high-fat, high-cholesterol diet
por: Houben, Tom, et al.
Publicado: (2019)

Increased Atherosclerotic Lesions in LDL Receptor Deficient Mice With Hematopoietic Nuclear Receptor Rev‐erbα Knock‐ Down
por: Ma, Hongling, et al.
Publicado: (2013)

Comment on Tauriainen et al.: Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD
por: Plat, Jogchum, et al.
Publicado: (2018)

NAFLD Preclinical Models: More than a Handful, Less of a Concern?
por: Oligschlaeger, Yvonne, et al.
Publicado: (2020)

NASH and Systemic Complications: From Basic to Clinical Research
por: Baumgartner, Sabine, et al.
Publicado: (2021)

The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical Trial
por: Shiri-Sverdlov, Ronit, et al.
Publicado: (2021)

Passive Immunization with Hypochlorite-oxLDL Specific Antibodies Reduces Plaque Volume in LDL Receptor-Deficient Mice
por: van Leeuwen, Marcella, et al.
Publicado: (2013)

All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma
por: van Mourik, Hester, et al.
Publicado: (2022)

Mediators of Gut Mucosal Immunity and Inflammation
por: Tekin, Ishak Ozel, et al.
Publicado: (2015)

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
por: Yadati, Tulasi, et al.
Publicado: (2020)

COVID‐19 infection, progression, and vaccination: Focus on obesity and related metabolic disturbances
por: Westheim, Annemarie J. F., et al.
Publicado: (2021)

Sex‐opposed inflammatory effects of 27‐hydroxycholesterol are mediated via differences in estrogen signaling
por: Houben, Tom, et al.
Publicado: (2020)

Cannabinoid Receptor 2 Deficiency in Haematopoietic cells Aggravates Early Atherosclerosis in LDL Receptor Deficient Mice
por: Delsing, Dianne J.M, et al.
Publicado: (2011)

High-frequency percussive ventilation in acute respiratory distress syndrome: knocking at the door but can it be let in?
por: Spapen, Herbert, et al.
Publicado: (2018)

Bone Marrow p16(INK4a)-Deficiency Does Not Modulate Obesity, Glucose Homeostasis or Atherosclerosis Development
por: Wouters, Kristiaan, et al.
Publicado: (2012)

Inflammatory Bowel Disease: A Stressed “Gut/Feeling”
por: Oligschlaeger, Yvonne, et al.
Publicado: (2019)

LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses
por: Wang, Shao-hua, et al.
Publicado: (2014)

Fatty Acids as a Tool to Boost Cancer Immunotherapy Efficacy
por: Westheim, Annemarie J. F., et al.
Publicado: (2022)

The Modulatory Effects of Fatty Acids on Cancer Progression
por: Westheim, Annemarie J. F., et al.
Publicado: (2023)

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
por: Bartuzi, Paulina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rnlfineh32j1n5hb4k2daljaht