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Activation of CD40 with Platelet Derived CD154 Promotes Reactive Oxygen Species Dependent Death of Human Hepatocytes during Hypoxia and Reoxygenation

BACKGROUND: Hypoxia and hypoxia-reoxygenation (H-R) are pathogenic factors in many liver diseases that lead to hepatocyte death as a result of reactive oxygen species (ROS) accumulation. The tumor necrosis factor super-family member CD154 can also induce hepatocyte apoptosis via activation of its re...

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Detalles Bibliográficos
Autores principales:	Bhogal, Ricky H., Weston, Christopher J., Curbishley, Stuart M., Adams, David H., Afford, Simon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266283/ https://www.ncbi.nlm.nih.gov/pubmed/22295117 http://dx.doi.org/10.1371/journal.pone.0030867

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