Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice

The aim of the present study was to evaluate the protective activity of aqueous extract from Platycodon grandiflorum (BC703) on thioacetamide (TA)-induced hepatotoxicity in mice. We found that BC703 significantly decreased mortality and the change in serum transaminase following TA administration. T...

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Detalles Bibliográficos
Autores principales: Lim, Jong-Hwan, Kim, Tae-Won, Park, Sang-Jin, Song, In-Bae, Kim, Myoung-Seok, Kwon, Hyo-Jung, Cho, Eun-Sang, Son, Hwa-Young, Lee, Sang-Wook, Suh, Joo-Won, Kim, Jong-Woo, Yun, Hyo-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2011
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266357/
https://www.ncbi.nlm.nih.gov/pubmed/22319234
http://dx.doi.org/10.1293/tox.24.223
Descripción
Sumario:The aim of the present study was to evaluate the protective activity of aqueous extract from Platycodon grandiflorum (BC703) on thioacetamide (TA)-induced hepatotoxicity in mice. We found that BC703 significantly decreased mortality and the change in serum transaminase following TA administration. The group treated with BC703 at doses of 1, 5, and 10 mg/kg produced significant hepatoprotective effects against TA-induced liver damage by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation in dose-dependent manners. Histopathological studies further substantiated the protective effect of BC703. These results show the hepatoprotective activity of aqueous extract from Platycodon grandiflorum on thioacetamide-induced fulminant hepatic failure.

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