Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys

Vacuolar degeneration of the thyroid follicular epithelium was observed in two untreated female cynomolgus monkeys assigned to control groups. In light microscopy, large vacuoles containing a homogenous substance occupied the basal region of the epithelium, and the nuclei had shifted toward the apic...

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Autores principales: Hatakeyama, Hirofumi, Takei, Yoshihiro, Cruz, Yumiko, Miyoshi, Seiji, Watanabe, Jun, Koizumi, Haruko, Shimoi, Akihito, Satoh, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266358/
https://www.ncbi.nlm.nih.gov/pubmed/22319235
http://dx.doi.org/10.1293/tox.24.229
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author Hatakeyama, Hirofumi
Takei, Yoshihiro
Cruz, Yumiko
Miyoshi, Seiji
Watanabe, Jun
Koizumi, Haruko
Shimoi, Akihito
Satoh, Hiroshi
author_facet Hatakeyama, Hirofumi
Takei, Yoshihiro
Cruz, Yumiko
Miyoshi, Seiji
Watanabe, Jun
Koizumi, Haruko
Shimoi, Akihito
Satoh, Hiroshi
author_sort Hatakeyama, Hirofumi
collection PubMed
description Vacuolar degeneration of the thyroid follicular epithelium was observed in two untreated female cynomolgus monkeys assigned to control groups. In light microscopy, large vacuoles containing a homogenous substance occupied the basal region of the epithelium, and the nuclei had shifted toward the apical region. The vacuoles showed negative reactions to PAS and thyroglobulin. Electron microscopic observation revealed dilatation of the rough endoplasmic reticulum corresponding to the vacuoles. The plasma TSH, T3 and T4 levels determined for the samples kept frozen were within the normal ranges, suggesting that the thyroid function was kept intact.
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spelling pubmed-32663582012-02-08 Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys Hatakeyama, Hirofumi Takei, Yoshihiro Cruz, Yumiko Miyoshi, Seiji Watanabe, Jun Koizumi, Haruko Shimoi, Akihito Satoh, Hiroshi J Toxicol Pathol Case Report Vacuolar degeneration of the thyroid follicular epithelium was observed in two untreated female cynomolgus monkeys assigned to control groups. In light microscopy, large vacuoles containing a homogenous substance occupied the basal region of the epithelium, and the nuclei had shifted toward the apical region. The vacuoles showed negative reactions to PAS and thyroglobulin. Electron microscopic observation revealed dilatation of the rough endoplasmic reticulum corresponding to the vacuoles. The plasma TSH, T3 and T4 levels determined for the samples kept frozen were within the normal ranges, suggesting that the thyroid function was kept intact. The Japanese Society of Toxicologic Pathology 2011-12 2012-01-07 /pmc/articles/PMC3266358/ /pubmed/22319235 http://dx.doi.org/10.1293/tox.24.229 Text en ©2011 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Case Report
Hatakeyama, Hirofumi
Takei, Yoshihiro
Cruz, Yumiko
Miyoshi, Seiji
Watanabe, Jun
Koizumi, Haruko
Shimoi, Akihito
Satoh, Hiroshi
Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys
title Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys
title_full Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys
title_fullStr Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys
title_full_unstemmed Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys
title_short Spontaneous Vacuolar Degeneration of the Thyroid Follicular Epithelium in Cynomolgus Monkeys
title_sort spontaneous vacuolar degeneration of the thyroid follicular epithelium in cynomolgus monkeys
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266358/
https://www.ncbi.nlm.nih.gov/pubmed/22319235
http://dx.doi.org/10.1293/tox.24.229
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