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A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor β Chain and p53 Double-knockout Mouse

A subcutaneous tumor was found in the right abdomen of a 16-week-old male TCRβ and p53 double-knockout mouse. The tumor had indistinct borders with the surrounding tissue. The cut surface after formalin fixation was pale yellowish white, partially dark red and partly white. Histologically, the tumor...

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Autores principales: Ando, Minoru, Kado, Shoichi, Suzuki, Tomo, Yamamoto, Ryota, Nagata, Yuriko, Hata, Chie, Uchida, Kazumi, Kaneko, Kimiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Toxicologic Pathology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266362/
https://www.ncbi.nlm.nih.gov/pubmed/22319239
http://dx.doi.org/10.1293/tox.24.251
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author Ando, Minoru
Kado, Shoichi
Suzuki, Tomo
Yamamoto, Ryota
Nagata, Yuriko
Hata, Chie
Uchida, Kazumi
Kaneko, Kimiyuki
author_facet Ando, Minoru
Kado, Shoichi
Suzuki, Tomo
Yamamoto, Ryota
Nagata, Yuriko
Hata, Chie
Uchida, Kazumi
Kaneko, Kimiyuki
author_sort Ando, Minoru
collection PubMed
description A subcutaneous tumor was found in the right abdomen of a 16-week-old male TCRβ and p53 double-knockout mouse. The tumor had indistinct borders with the surrounding tissue. The cut surface after formalin fixation was pale yellowish white, partially dark red and partly white. Histologically, the tumor was composed of three distinct regions. The first region showed pleomorphic cells arranged in sheets. The second region showed spindle cells arranged in interlacing fascicles. The final region contained a mixture of the above mentioned two types of cells. Furthermore, a small amount of collagen fibers, round cells, multinucleated giant cells, and cells with eosinophilic granules were observed between these tumor cells. Immunohistochemical examination and electron microscopy identified that the pleomorphic cells and spindle cells were histiocytes and fibroblasts, respectively, and that the round cells were undifferentiated mesenchymal cells. Based on these findings, the tumor was diagnosed as a malignant fibrous histiocytoma.
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spelling pubmed-32663622012-02-08 A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor β Chain and p53 Double-knockout Mouse Ando, Minoru Kado, Shoichi Suzuki, Tomo Yamamoto, Ryota Nagata, Yuriko Hata, Chie Uchida, Kazumi Kaneko, Kimiyuki J Toxicol Pathol Case Report A subcutaneous tumor was found in the right abdomen of a 16-week-old male TCRβ and p53 double-knockout mouse. The tumor had indistinct borders with the surrounding tissue. The cut surface after formalin fixation was pale yellowish white, partially dark red and partly white. Histologically, the tumor was composed of three distinct regions. The first region showed pleomorphic cells arranged in sheets. The second region showed spindle cells arranged in interlacing fascicles. The final region contained a mixture of the above mentioned two types of cells. Furthermore, a small amount of collagen fibers, round cells, multinucleated giant cells, and cells with eosinophilic granules were observed between these tumor cells. Immunohistochemical examination and electron microscopy identified that the pleomorphic cells and spindle cells were histiocytes and fibroblasts, respectively, and that the round cells were undifferentiated mesenchymal cells. Based on these findings, the tumor was diagnosed as a malignant fibrous histiocytoma. The Japanese Society of Toxicologic Pathology 2011-12 2012-01-07 /pmc/articles/PMC3266362/ /pubmed/22319239 http://dx.doi.org/10.1293/tox.24.251 Text en ©2011 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Case Report
Ando, Minoru
Kado, Shoichi
Suzuki, Tomo
Yamamoto, Ryota
Nagata, Yuriko
Hata, Chie
Uchida, Kazumi
Kaneko, Kimiyuki
A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor β Chain and p53 Double-knockout Mouse
title A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor β Chain and p53 Double-knockout Mouse
title_full A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor β Chain and p53 Double-knockout Mouse
title_fullStr A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor β Chain and p53 Double-knockout Mouse
title_full_unstemmed A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor β Chain and p53 Double-knockout Mouse
title_short A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor β Chain and p53 Double-knockout Mouse
title_sort case report of a malignant fibrous histiocytoma in a t-cell receptor β chain and p53 double-knockout mouse
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266362/
https://www.ncbi.nlm.nih.gov/pubmed/22319239
http://dx.doi.org/10.1293/tox.24.251
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