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Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans

Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell dysfunction, the latter possibly caused by a defect in insulin signaling in β-cells. We hypothesized that insulin’s effect to potentiate glucose-stimulated insulin secretion (GSIS) would be diminished in insulin-resis...

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Detalles Bibliográficos
Autores principales:	Halperin, Florencia, Lopez, Ximena, Manning, Raquel, Kahn, C. Ronald, Kulkarni, Rohit N., Goldfine, Allison B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266415/ https://www.ncbi.nlm.nih.gov/pubmed/22275085 http://dx.doi.org/10.2337/db11-1067

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