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Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B(12 )and folic acid on fracture incidence

BACKGROUND: Osteoporosis is a major health problem, and the economic burden is expected to rise due to an increase in life expectancy throughout the world. Current observational evidence suggests that an elevated homocysteine concentration and poor vitamin B(12 )and folate status are associated with...

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Detalles Bibliográficos
Autores principales:	van Wijngaarden, Janneke P, Dhonukshe-Rutten, Rosalie AM, van Schoor, Natasja M, van der Velde, Nathalie, Swart, Karin MA, Enneman, Anke W, van Dijk, Suzanne C, Brouwer-Brolsma, Elske M, Zillikens, M Carola, van Meurs, Joyce BJ, Brug, Johannes, Uitterlinden, André G, Lips, Paul, de Groot, Lisette CPGM
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266639/ https://www.ncbi.nlm.nih.gov/pubmed/22136481 http://dx.doi.org/10.1186/1471-2318-11-80

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