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Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation

The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced sodium channel inhibition decreases the rate of cardiomyocyte depolarization and consequently conduction velocity and can have serious implicat...

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Detalles Bibliográficos
Autores principales:	Erdemli, Gül, Kim, Albert M., Ju, Haisong, Springer, Clayton, Penland, Robert C., Hoffmann, Peter K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266668/ https://www.ncbi.nlm.nih.gov/pubmed/22303294 http://dx.doi.org/10.3389/fphar.2012.00006

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