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Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging. However, the role of heterochromatin in animal aging has been controversial. Here we show that heterochromatin formation prolongs lifespan an...

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Detalles Bibliográficos
Autores principales: Larson, Kimberly, Yan, Shian-Jang, Tsurumi, Amy, Liu, Jacqueline, Zhou, Jun, Gaur, Kriti, Guo, Dongdong, Eickbush, Thomas H., Li, Willis X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266895/
https://www.ncbi.nlm.nih.gov/pubmed/22291607
http://dx.doi.org/10.1371/journal.pgen.1002473