Cargando…

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating virus growth remains unresolved. Here, we adopt two approaches to investigate whether IFI16 exerts pro- and/or anti-viral actions. First, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gariano, Grazia Rosaria, Dell'Oste, Valentina, Bronzini, Matteo, Gatti, Deborah, Luganini, Anna, De Andrea, Marco, Gribaudo, Giorgio, Gariglio, Marisa, Landolfo, Santo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266931/ https://www.ncbi.nlm.nih.gov/pubmed/22291595 http://dx.doi.org/10.1371/journal.ppat.1002498

Ejemplares similares

Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding
por: Gugliesi, Francesca, et al.
Publicado: (2013)

IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection
por: Griffante, Gloria, et al.
Publicado: (2022)

Past and ongoing adaptation of human cytomegalovirus to its host
por: Mozzi, Alessandra, et al.
Publicado: (2020)

The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1β by Human Cytomegalovirus through Inhibition of NF-kB Activity
por: Biolatti, Matteo, et al.
Publicado: (2018)

PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma
por: Riva, Giuseppe, et al.
Publicado: (2019)

Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding
por: Iannucci, Andrea, et al.
Publicado: (2020)

Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection
por: Biolatti, Matteo, et al.
Publicado: (2020)

Bioactive Molecules Released From Cells Infected with the Human Cytomegalovirus
por: Luganini, Anna, et al.
Publicado: (2016)

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication
por: Griffante, Gloria, et al.
Publicado: (2021)

Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship
por: Rossini, Giada, et al.
Publicado: (2012)

Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells
por: Funaro, Ada, et al.
Publicado: (2008)

IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation
por: Piccaluga, Pier Paolo, et al.
Publicado: (2015)

Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on “The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts”
por: Mercorelli, Beatrice, et al.
Publicado: (2019)

Genetic Variability of Human Cytomegalovirus Clinical Isolates Correlates With Altered Expression of Natural Killer Cell-Activating Ligands and IFN-γ
por: Galitska, Ganna, et al.
Publicado: (2021)

Human Cytomegalovirus and Autoimmune Diseases: Where Are We?
por: Gugliesi, Francesca, et al.
Publicado: (2021)

HPV Meets APOBEC: New Players in Head and Neck Cancer
por: Riva, Giuseppe, et al.
Publicado: (2021)

The US21 viroporin of human cytomegalovirus stimulates cell migration and adhesion
por: Luganini, Anna, et al.
Publicado: (2023)

The Absent in Melanoma 2-Like Receptor IFN-Inducible Protein 16 as an Inflammasome Regulator in Systemic Lupus Erythematosus: The Dark Side of Sensing Microbes
por: Caneparo, Valeria, et al.
Publicado: (2018)

Retroviruses of the Human Virobiota: The Recycling of Viral Genes and the Resulting Advantages for Human Hosts During Evolution
por: Luganini, Anna, et al.
Publicado: (2020)

Strigolactones, from Plants to Human Health: Achievements and Challenges
por: Dell’Oste, Valentina, et al.
Publicado: (2021)

Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2
por: Pasquero, Selina, et al.
Publicado: (2022)

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity
por: De Meo, Simone, et al.
Publicado: (2020)

Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma
por: Piccaluga, Pier Paolo, et al.
Publicado: (2019)

Invasive fungal infection (IFI) in pediatric leukemia: better outcome with ACT
por: Shin, Ok Sarah
Publicado: (2017)

The Novel hDHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis
por: Sibille, Giulia, et al.
Publicado: (2022)

Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism
por: Fanunza, Elisa, et al.
Publicado: (2023)

Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism
por: Fanunza, Elisa, et al.
Publicado: (2023)

Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans
por: Stadion, Mandy, et al.
Publicado: (2018)

Risk and Protective Factors for PTSD in Caregivers of Adult Patients with Severe Medical Illnesses: A Systematic Review
por: Carmassi, Claudia, et al.
Publicado: (2020)

Telomeres get SIRT-ified
por: Short, Ben
Publicado: (2010)

Mania Following Bereavement: State of the Art and Clinical Evidence
por: Carmassi, Claudia, et al.
Publicado: (2020)

Suicidality and Illness Course Worsening in a Male Patient with Bipolar Disorder during Tamoxifen Treatment for ER+/HER2+ Breast Cancer
por: Carmassi, Claudia, et al.
Publicado: (2021)

Mental Health Symptoms among General Practitioners Facing the Acute Phase of the COVID-19 Pandemic: Detecting Different Reaction Groups
por: Carmassi, Claudia, et al.
Publicado: (2022)

International fitness scale (IFIS): association with motor performance in children with obesity
por: Puci, Mariangela Valentina, et al.
Publicado: (2023)

Intrinsic Immune Mechanisms Restricting Human Cytomegalovirus Replication
por: Schilling, Eva-Maria, et al.
Publicado: (2021)

PTSD symptoms in healthcare workers facing the three coronavirus outbreaks: What can we expect after the COVID-19 pandemic
por: Carmassi, Claudia, et al.
Publicado: (2020)

PTSD and Suicidal Behaviors Amongst L'Aquila 2009 Earthquake Young Survivors
por: Carmassi, Claudia, et al.
Publicado: (2021)

Interferon gamma-inducible protein 16 in primary Sjögren’s syndrome: a novel player in disease pathogenesis?
por: Alunno, Alessia, et al.
Publicado: (2015)

Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection
por: Merkl, Philipp E., et al.
Publicado: (2019)

Porcine IFI16 Negatively Regulates cGAS Signaling Through the Restriction of DNA Binding and Stimulation
por: Zheng, Wanglong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_01vnnjkd64v74jps4j75hm8n3p