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Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analogues

In optimal cases, bivalent ligands can bind with exceptionally high affinity to their protein targets. However, designing optimised linkers, that orient the two binding groups perfectly, is challenging, and yet crucial in both fragment-based ligand design and in the discovery of bisubstrate enzyme i...

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Detalles Bibliográficos
Autores principales:	Joce, Catherine, White, Rebecca, Stockley, Peter G., Warriner, Stuart, Turnbull, W. Bruce, Nelson, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267017/ https://www.ncbi.nlm.nih.gov/pubmed/22137339 http://dx.doi.org/10.1016/j.bmcl.2011.11.017

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