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Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

Secreted signals, known as morphogens, provide the positional information that organizes gene expression and cellular differentiation in many developing tissues. In the vertebrate neural tube, Sonic Hedgehog (Shh) acts as a morphogen to control the pattern of neuronal subtype specification. Using an...

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Detalles Bibliográficos
Autores principales: Balaskas, Nikolaos, Ribeiro, Ana, Panovska, Jasmina, Dessaud, Eric, Sasai, Noriaki, Page, Karen M., Briscoe, James, Ribes, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267043/
https://www.ncbi.nlm.nih.gov/pubmed/22265416
http://dx.doi.org/10.1016/j.cell.2011.10.047