Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

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Tuberculosis continues to be a global health threat, making bicyclic nitroimidazoles an important new class of therapeutics. A deazaflavin-dependent nitroreductase (Ddn) from Mycobacterium tuberculosis catalyzes the reduction of nitroimidazoles such as PA-824, resulting in intracellular release of l...

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Detalles Bibliográficos
Autores principales: Cellitti, Susan E., Shaffer, Jennifer, Jones, David H., Mukherjee, Tathagata, Gurumurthy, Meera, Bursulaya, Badry, Boshoff, Helena I., Choi, Inhee, Nayyar, Amit, Lee, Yong Sok, Cherian, Joseph, Niyomrattanakit, Pornwaratt, Dick, Thomas, Manjunatha, Ujjini H., Barry, Clifton E., Spraggon, Glen, Geierstanger, Bernhard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267046/
https://www.ncbi.nlm.nih.gov/pubmed/22244759
http://dx.doi.org/10.1016/j.str.2011.11.001
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