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BACE1 Processing of NRG1 Type III Produces a Myelin-Inducing Signal but Is Not Essential for the Stimulation of Myelination
Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous system, neuregulin 1 (NRG1) type III is a key regulator of this process. It has been proposed that the protease BACE1 activates NRG1 dependent myelination. Here, we characterize the predicted product of BACE...
Autores principales: | Velanac, Viktorija, Unterbarnscheidt, Tilmann, Hinrichs, Wilko, Gummert, Maike N, Fischer, Tobias M, Rossner, Moritz J, Trimarco, Amelia, Brivio, Veronica, Taveggia, Carla, Willem, Michael, Haass, Christian, Möbius, Wiebke, Nave, Klaus-Armin, Schwab, Markus H |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267053/ https://www.ncbi.nlm.nih.gov/pubmed/22052506 http://dx.doi.org/10.1002/glia.21255 |
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